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Drug Name Acalabrutinib
Trade Name Calquence
Synonyms ACP-196
Drug Descriptions

Calquence (acalabrutinib) selectively inhibits BTK, resulting in decreased B-cell receptor signaling, and potentially leading to decreased tumor cell proliferation (PMID: 27903679, PMID: 26957112). Calquence (acalabrutinib) is FDA approved for use in patients with mantle cell lymphoma, chronic lymphocytic leukemia or small lymphocytic lymphoma (FDA.gov).

DrugClasses BTK inhibitor 22

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Acalabrutinib Acalabrutinib 3 23
Acalabrutinib + ACP-319 ACP-319 Acalabrutinib 1 0
Acalabrutinib + AZD6738 AZD6738 Acalabrutinib 0 1
Acalabrutinib + AZD9150 AZD9150 Acalabrutinib 0 1
Acalabrutinib + Bendamustine + Cytarabine + Rituximab Acalabrutinib Bendamustine Cytarabine Rituximab 0 2
Acalabrutinib + Bendamustine + Rituximab Acalabrutinib Bendamustine Rituximab 0 3
Acalabrutinib + Carboplatin + Etoposide + Ifosfamide + Rituximab Acalabrutinib Carboplatin Etoposide Ifosfamide Rituximab 0 2
Acalabrutinib + Cyclophosphamide + Doxorubicin + Etoposide + Prednisone + Rituximab + Vincristine Acalabrutinib Cyclophosphamide Doxorubicin Etoposide Prednisone Rituximab Vincristine 0 1
Acalabrutinib + Cyclophosphamide + Doxorubicin + Prednisone + Rituximab + Vincristine Acalabrutinib Cyclophosphamide Doxorubicin Prednisone Rituximab Vincristine 0 1
Acalabrutinib + KTE-C19 Acalabrutinib KTE-C19 0 1
Acalabrutinib + Lenalidomide + Rituximab Acalabrutinib Lenalidomide Rituximab 0 1
Acalabrutinib + Obinutuzumab Acalabrutinib Obinutuzumab 1 2
Acalabrutinib + Obinutuzumab + Venetoclax Acalabrutinib Obinutuzumab Venetoclax 0 3
Acalabrutinib + Pembrolizumab Acalabrutinib Pembrolizumab 1 0
Acalabrutinib + Rituximab Acalabrutinib Rituximab 0 1
Acalabrutinib + Venetoclax Acalabrutinib Venetoclax 0 2
Acalabrutinib + Vistusertib Acalabrutinib Vistusertib 0 1


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