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Drug Name Umbralisib
Trade Name
Synonyms RP5264|TGR-1202
Drug Descriptions

Umbralisib (TGR-1202) is a selective inhibitor of PIK3CD, which prevents Akt phosphorylation and induces cytotoxicity (J Clin Oncol 32:5s, 2014 (suppl; abstr 2513), PMID: 30709431).

DrugClasses PIK3CD inhibitor 25

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Brentuximab vedotin + Umbralisib Brentuximab vedotin Umbralisib 1 0
Carfilzomib + Umbralisib Carfilzomib Umbralisib 0 1
Chlorambucil + Obinutuzumab + Umbralisib Chlorambucil Obinutuzumab Umbralisib 0 1
Ibrutinib + Ublituximab + Umbralisib Ibrutinib Ublituximab Umbralisib 1 1
Ibrutinib + Umbralisib Ibrutinib Umbralisib 0 2
Obinutuzumab + Umbralisib Obinutuzumab Umbralisib 0 1
Pembrolizumab + Ublituximab + Umbralisib Pembrolizumab Ublituximab Umbralisib 0 1
Pembrolizumab + Umbralisib Pembrolizumab Umbralisib 0 2
Rituximab + Umbralisib Rituximab Umbralisib 0 1
Ruxolitinib + Umbralisib Ruxolitinib Umbralisib 0 1
Ublituximab + Umbralisib Ublituximab Umbralisib 3 6
Ublituximab + Umbralisib + Venetoclax Ublituximab Umbralisib Venetoclax 0 3
Umbralisib Umbralisib 10 10


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