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Drug Name Umbralisib
Trade Name Ukoniq
Synonyms RP5264|TGR-1202
Drug Descriptions

Ukoniq (umbralisib) is a selective inhibitor of PIK3CD, which prevents Akt phosphorylation and induces cytotoxicity (J Clin Oncol 32:5s, 2014 (suppl; abstr 2513), PMID: 30709431). Ukoniq (umbralisib) is FDA approved for use in adult patients with relapsed or refractory marginal zone lymphoma with one or more prior anti-CD20-based therapy, and in adult patients with relapsed or refractory follicular lymphoma who have three or more prior lines of therapy (FDA.gov).

DrugClasses PIK3CD inhibitor 27
CAS Registry Number 1532533-67-7
NCIT ID C104413


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Acalabrutinib + Ublituximab + Umbralisib Acalabrutinib Ublituximab Umbralisib 0 2
Brentuximab vedotin + Umbralisib Brentuximab vedotin Umbralisib 0 0
CA-4948 + Umbralisib CA-4948 Umbralisib 0 0
Carfilzomib + Umbralisib Carfilzomib Umbralisib 0 1
Chlorambucil + Obinutuzumab + Umbralisib Chlorambucil Obinutuzumab Umbralisib 0 1
Cyclophosphamide + Doxorubicin + Prednisone + Ublituximab + Umbralisib + Vincristine Sulfate Cyclophosphamide Doxorubicin Prednisone Ublituximab Umbralisib Vincristine Sulfate 0 1
Edralbrutinib + Ublituximab + Umbralisib Edralbrutinib Ublituximab Umbralisib 0 1
Ibrutinib + Ublituximab + Umbralisib Ibrutinib Ublituximab Umbralisib 0 1
Ibrutinib + Umbralisib Ibrutinib Umbralisib 0 2
Lenalidomide + Ublituximab + Umbralisib Lenalidomide Ublituximab Umbralisib 0 1
Loncastuximab tesirine-lpyl + Umbralisib Loncastuximab tesirine-lpyl Umbralisib 0 1
Obinutuzumab + Umbralisib Obinutuzumab Umbralisib 0 1
Pembrolizumab + Ublituximab + Umbralisib Pembrolizumab Ublituximab Umbralisib 0 1
Pembrolizumab + Umbralisib Pembrolizumab Umbralisib 0 2
Rituximab + Umbralisib Rituximab Umbralisib 0 1
Ruxolitinib + Umbralisib Ruxolitinib Umbralisib 0 1
Tazemetostat + Ublituximab + Umbralisib Tazemetostat Ublituximab Umbralisib 0 1
Ublituximab + Umbralisib Ublituximab Umbralisib 0 7
Ublituximab + Umbralisib + Venetoclax Ublituximab Umbralisib Venetoclax 0 3
Umbralisib Umbralisib 0 10

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