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Drug Name CA-4948
Trade Name
Synonyms CA4948|CA 4948|Emavusertib|AU 4948|AU4948|AU-4948
Drug Descriptions

CA-4948 inhibits IRAK4, thereby blocking TLR and IL-1R signaling, potentially resulting in tumor regression (PMID: 33335659).

DrugClasses IRAK4 Inhibitor 7
CAS Registry Number 1801343-74-7
NCIT ID C148455


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Therapy Name Drugs Efficacy Evidence Clinical Trials
CA-4948 CA-4948 0 3
CA-4948 + Fluorouracil + Leucovorin + Nivolumab + Oxaliplatin CA-4948 Fluorouracil Leucovorin Nivolumab Oxaliplatin 0 1
CA-4948 + Fluorouracil + Leucovorin + Oxaliplatin + Pembrolizumab + Trastuzumab CA-4948 Fluorouracil Leucovorin Oxaliplatin Pembrolizumab Trastuzumab 0 1
CA-4948 + Gemcitabine + Nab-paclitaxel CA-4948 Gemcitabine Nab-paclitaxel 0 1
CA-4948 + Ibrutinib CA-4948 Ibrutinib 0 0
CA-4948 + Idelalisib CA-4948 Idelalisib 0 0
CA-4948 + Pembrolizumab CA-4948 Pembrolizumab 0 1
CA-4948 + Umbralisib CA-4948 Umbralisib 0 0
CA-4948 + Venetoclax CA-4948 Venetoclax 0 0

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