Drug Detail


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Drug Name Idelalisib
Trade Name Zydelig
Synonyms CAL-101|GS-1101
Drug Descriptions

Zydelig (idelalisib) inhibits PI3K-delta, preventing the activation of the PI3K signaling pathway and inhibiting tumor cell proliferation, motility, and survival (PMID: 24450857). Zydelig (idelalisib) is FDA approved for follicular B-cell non-Hodgkin lymphoma, relapsed small lymphocytic lymphoma, and in combination with Rituxan (rituximab) for relapsed chronic lymphocytic leukemia (FDA.gov).

DrugClasses PIK3CD inhibitor 27
CAS Registry Number 870281-82-6
NCIT ID C78825


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Therapy Name Drugs Efficacy Evidence Clinical Trials
BCL201 + Idelalisib BCL201 Idelalisib 0 1
Bendamustine + Idelalisib + Rituximab Bendamustine Idelalisib Rituximab 0 2
BI 836826 + Idelalisib BI 836826 Idelalisib 0 1
CA-4948 + Idelalisib CA-4948 Idelalisib 0 0
Entospletinib + Idelalisib Entospletinib Idelalisib 0 0
GSK2334470 + Idelalisib GSK2334470 Idelalisib 1 0
Idelalisib Idelalisib 4 10
Idelalisib + Lapatinib Idelalisib Lapatinib 0 0
Idelalisib + Loncastuximab tesirine-lpyl Idelalisib Loncastuximab tesirine-lpyl 0 0
Idelalisib + MK2206 Idelalisib MK2206 1 0
Idelalisib + Obinutuzumab Idelalisib Obinutuzumab 0 1
Idelalisib + Obinutuzumab + Tirabrutinib Idelalisib Obinutuzumab Tirabrutinib 0 1
Idelalisib + Ofatumumab Idelalisib Ofatumumab 0 1
Idelalisib + Otlertuzumab + Rituximab Idelalisib Otlertuzumab Rituximab 0 1
Idelalisib + Pembrolizumab Idelalisib Pembrolizumab 0 1
Idelalisib + Ricolinostat Idelalisib Ricolinostat 0 1
Idelalisib + Rituximab Idelalisib Rituximab 3 3
Idelalisib + Rituximab + Venetoclax Idelalisib Rituximab Venetoclax 0 1
Idelalisib + Tafasitamab-cxix Idelalisib Tafasitamab-cxix 0 1
Idelalisib + Tazemetostat Idelalisib Tazemetostat 0 0
Idelalisib + Tirabrutinib Idelalisib Tirabrutinib 0 1

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