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|Therapy Name||Idelalisib + Rituximab|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Idelalisib||Zydelig||CAL-101|GS-1101||PIK3CD inhibitor 25||Zydelig (idelalisib) inhibits PI3K-delta, preventing the activation of the PI3K signaling pathway and inhibiting tumor cell proliferation, motility, and survival (PMID: 24450857). Zydelig (idelalisib) is FDA approved for follicular B-cell non-Hodgkin lymphoma, relapsed small lymphocytic lymphoma, and in combination with Rituxan (rituximab) for relapsed chronic lymphocytic leukemia (FDA.gov).|
|Rituximab||Rituxan||IDEC-C2B8|MabThera||CD20 Antibody 10||Rituxan (rituximab) is a chimeric mononclonal antibody that binds to CD20 on B-cells, resulting in induction of complement-dependent and antibody-dependent cytotoxicity, and potentially leading to decreased B-cell tumor growth (PMID: 28983798). Rituxan (rituximab) is FDA approved for use as monotherapy or in combination with chemotherapy in CD20-positive B-cell non-Hodgkin lymphoma, and in combination with fludarabine and cyclophosphamide in CD20-positive chronic lymphocytic leukemia (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||chronic lymphocytic leukemia||not applicable||Idelalisib + Rituximab||FDA approved||Actionable||In a Phase III trial that supported FDA approval, Zydelig (idelalisib) and Rituxan (rituximab) combination therapy resulted in improved overall response rate (81%) and overall survival at 12 months (92%) when compared to Rituxan (rituximab) plus placebo (13% and 80%, respectively) in patients with relapsed chronic lymphocytic leukemia (PMID: 24450857; NCT01539512).||detail... 24450857|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|
|NCT02044822||Phase II||Idelalisib + Rituximab||Efficacy and Safety of Idelalisib in Combination With Rituximab in Patients With Previously Untreated Chronic Lymphocytic Leukemia With 17p Deletion||Terminated|