Therapy Detail

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Therapy Name LOXO-305
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
LOXO-305 LOXO 305|LOXO305|pirtobrutinib BTK inhibitor 32 LOXO-305 selectively inhibits activation of BTK, which results in decreased tumor growth (PMID: 32170458, PMID: 33676628).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BTK V416L diffuse large B-cell lymphoma resistant LOXO-305 Preclinical - Cell culture Actionable In a preclinical study, a diffuse large B-cell lymphoma cell line expressing BTK V416L demonstrated resistance to LOXO-305 in culture (PMID: 35196427). 35196427
BTK T474I diffuse large B-cell lymphoma resistant LOXO-305 Preclinical - Cell culture Actionable In a preclinical study, a diffuse large B-cell lymphoma cell line expressing BTK T474I demonstrated resistance to LOXO-305 in culture (PMID: 35196427). 35196427
BTK M437R chronic lymphocytic leukemia predicted - resistant LOXO-305 Case Reports/Case Series Actionable In a clinical case study, a patient with chronic lymphocytic leukemia harboring BTK C481S who previously responded to LOXO-305 treatment was found to have acquired BTK M437R upon disease progression (PMID: 35196427). 35196427
BTK L528W diffuse large B-cell lymphoma resistant LOXO-305 Preclinical - Cell culture Actionable In a preclinical study, a diffuse large B-cell lymphoma cell line expressing BTK L528W demonstrated resistance to LOXO-305 in culture (PMID: 35196427). 35196427
BTK C481S diffuse large B-cell lymphoma sensitive LOXO-305 Preclinical - Cell culture Actionable In a preclinical study, LOXO-305 treatment inhibited viability of a diffuse large B-cell lymphoma cell line harboring BTK C481S in culture (PMID: 35196427). 35196427
BTK V416L chronic lymphocytic leukemia predicted - resistant LOXO-305 Case Reports/Case Series Actionable In a clinical case study, a patient with chronic lymphocytic leukemia who previously responded to LOXO-305 treatment was found to have acquired a BTK V416L upon disease progression (PMID: 35196427). 35196427
BTK L528W chronic lymphocytic leukemia predicted - resistant LOXO-305 Case Reports/Case Series Actionable In a clinical case study, two patients with chronic lymphocytic leukemia who previously responded to LOXO-305 treatment were found to have acquired BTK L528W upon disease progression (PMID: 35196427). 35196427
BTK A428D diffuse large B-cell lymphoma resistant LOXO-305 Preclinical - Cell culture Actionable In a preclinical study, a diffuse large B-cell lymphoma cell line expressing BTK A428D demonstrated resistance to LOXO-305 in culture (PMID: 35196427). 35196427
BTK M437R diffuse large B-cell lymphoma resistant LOXO-305 Preclinical - Cell culture Actionable In a preclinical study, a diffuse large B-cell lymphoma cell line expressing BTK M437R demonstrated resistance to LOXO-305 in culture (PMID: 35196427). 35196427
BTK T474I BTK L528W chronic lymphocytic leukemia predicted - resistant LOXO-305 Case Reports/Case Series Actionable In a clinical case study, a patient with chronic lymphocytic leukemia harboring BTK C481S who previously responded to LOXO-305 treatment was found to have acquired BTK T474I and BTK L528W upon disease progression (PMID: 35196427). 35196427
BTK T474I chronic lymphocytic leukemia predicted - resistant LOXO-305 Case Reports/Case Series Actionable In a clinical case study, two patients with chronic lymphocytic leukemia who previously responded to LOXO-305 treatment were found to have acquired BTK T474I upon disease progression (PMID: 35196427). 35196427

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

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  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04662255 Phase III Ibrutinib Zanubrutinib LOXO-305 Acalabrutinib Study of BTK Inhibitor LOXO-305 Versus Approved BTK Inhibitor Drugs in Patients With Mantle Cell Lymphoma (MCL) (BRUIN-MCL-321) Recruiting USA | ITA | FRA | ESP | DEU | CAN | BEL | AUT 16
NCT05023980 Phase III LOXO-305 Bendamustine + Rituximab A Study of Pirtobrutinib (LOXO-305) Versus Bendamustine Plus Rituximab (BR) in Untreated Patients With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) (BRUIN CLL-313) Recruiting USA | ITA | FRA | ESP | AUT 10
NCT05172700 Expanded access LOXO-305 Expanded Access Program for Pirtobrutinib for Participants With B-Cell Cancer Available USA | DEU | BEL 5
NCT05254743 Phase III Ibrutinib LOXO-305 A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) (BRUIN-CLL-314) Recruiting USA 0
NCT04666038 Phase III Idelalisib + Rituximab LOXO-305 Bendamustine + Rituximab Study of LOXO-305 Versus Investigator's Choice (IdelaR or BR) in Patients With CLL or SLL Recruiting USA | ITA | FRA | ESP | DEU | CAN | BEL | AUT 14
NCT03740529 Phase Ib/II Cyclophosphamide + Doxorubicin + LOXO-305 + Prednisone + Rituximab + Vincristine Sulfate LOXO-305 + Rituximab + Venetoclax LOXO-305 + Venetoclax LOXO-305 A Study of Oral LOXO-305 in Patients With Previously Treated CLL/SLL or NHL Recruiting USA | ITA | FRA 7


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