Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Entospletinib
Trade Name
Synonyms GS-9973|GS 9973|GS9973
Drug Descriptions

Entospletinib (GS-9973) is a selective spleen tyrosine kinase (Syk) inhibitor, which in turn inhibits B-cell receptor signaling, leading to suppression of cell migration and inhibition of survival (PMID: 24779514, PMID: 32156743).

DrugClasses SYK Inhibitor 15
CAS Registry Number 1229208-44-9
NCIT ID C105402


  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")


  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Anthracycline + Cyclophosphamide + Entospletinib Anthracycline Cyclophosphamide Entospletinib 0 0
Anthracycline + Cytarabine + Entospletinib Anthracycline Cytarabine Entospletinib 0 1
Azacitidine + Entospletinib Azacitidine Entospletinib 0 1
Entospletinib Entospletinib 2 2
Entospletinib + Idelalisib Entospletinib Idelalisib 0 0
Entospletinib + Midostaurin Entospletinib Midostaurin 1 0
Entospletinib + Obinutuzumab Entospletinib Obinutuzumab 0 1
Entospletinib + Obinutuzumab + Tirabrutinib Entospletinib Obinutuzumab Tirabrutinib 0 1
Entospletinib + Tirabrutinib Entospletinib Tirabrutinib 0 1

Additional content available in CKB BOOST