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Drug Name Entospletinib
Trade Name
Synonyms GS-9973|GS 9973|GS9973
Drug Descriptions

Entospletinib (GS-9973) is a selective spleen tyrosine kinase (Syk) inhibitor, which in turn inhibits B-cell receptor signaling, leading to suppression of cell migration and inhibition of survival (PMID: 24779514, PMID: 32156743).

DrugClasses SYK Inhibitor 14

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Azacitidine + Entospletinib Azacitidine Entospletinib 0 1
Entospletinib Entospletinib 6 2
Entospletinib + Idelalisib Entospletinib Idelalisib 2 0
Entospletinib + Midostaurin Entospletinib Midostaurin 1 0
Entospletinib + Obinutuzumab Entospletinib Obinutuzumab 0 1
Entospletinib + Obinutuzumab + Tirabrutinib Entospletinib Obinutuzumab Tirabrutinib 0 1
Entospletinib + Tirabrutinib Entospletinib Tirabrutinib 1 1


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