Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Midostaurin
Trade Name Rydapt
Synonyms PKC412|CGP 41251
Drug Descriptions

Rydapt (midostaurin) is a multi-kinase inhibitor with activity against FLT3, KIT, PDGFRB, KDR (VEGFR2) and PKC, with higher selectivity for conventional PKC isoforms, which induces cell cycle arrest and apoptosis (PMID: 12124173, PMID: 23127174, PMID: 15914319). Rydapt (midostaurin) is FDA approved for FLT3-mutant AML in combination with chemotherapy, and is approved for use in aggressive systemic mastocytosis, systemic mastocytosis with associated hematological neoplasm, or mast cell leukemia as a single therapy (FDA.gov).

DrugClasses CSF1R Inhibitor 28 FLT3 Inhibitor 66 KIT Inhibitor 57 PKC alpha Inhibitor 6 PKC beta Inhibitor 6 PKC Inhibitor (Pan) 11 VEGFR2 Inhibitor 37
CAS Registry Number 120685-11-2


  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")


  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Azacitidine + Midostaurin Azacitidine Midostaurin 1 2
BMS-754807 + Midostaurin BMS-754807 Midostaurin 0 0
Bortezomib + Cytarabine + Etoposide + Midostaurin + Mitoxantrone Bortezomib Cytarabine Etoposide Midostaurin Mitoxantrone 0 0
Busulfan + CPX-351 + Fludarabine + Melphalan + Midostaurin Busulfan CPX-351 Fludarabine Melphalan Midostaurin 0 1
CPX-351 + Midostaurin CPX-351 Midostaurin 0 1
Cytarabine + Daunorubicin + Gemtuzumab ozogamicin + Midostaurin Cytarabine Daunorubicin Gemtuzumab ozogamicin Midostaurin 0 1
Cytarabine + Daunorubicin + Midostaurin Cytarabine Daunorubicin Midostaurin 31 1
Cytarabine + Daunorubicin + Midostaurin + Revumenib Cytarabine Daunorubicin Midostaurin Revumenib 0 0
Cytarabine + Idarubicin + Midostaurin Cytarabine Idarubicin Midostaurin 1 1
Cytarabine + Midostaurin Cytarabine Midostaurin 12 1
Cytarabine + Midostaurin + Revumenib Cytarabine Midostaurin Revumenib 0 0
Daunorubicin + Midostaurin Daunorubicin Midostaurin 0 1
Decitabine + Midostaurin Decitabine Midostaurin 0 2
Entospletinib + Midostaurin Entospletinib Midostaurin 1 0
Linsitinib + Midostaurin Linsitinib Midostaurin 0 0
Midostaurin Midostaurin 110 13
Midostaurin + Palbociclib Midostaurin Palbociclib 0 0
Midostaurin + PRT062607 Midostaurin PRT062607 3 0
Midostaurin + Ruxolitinib Midostaurin Ruxolitinib 2 0
Midostaurin + SCH772984 Midostaurin SCH772984 0 0
Midostaurin + Tofacitinib Midostaurin Tofacitinib 2 0

Additional content available in CKB BOOST