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Drug Name Midostaurin
Trade Name Rydapt
Synonyms PKC412|CGP 41251
Drug Descriptions

Rydapt (midostaurin) is a multi-kinase inhibitor with activity against FLT3, KIT, PDGFRB, KDR (VEGFR2) and PKC, with higher selectivity for conventional PKC isoforms, which induces cell cycle arrest and apoptosis (PMID: 12124173, PMID: 23127174, PMID: 15914319). Rydapt (midostaurin) is FDA approved for FLT3-mutant AML in combination with chemotherapy, and is approved for use in aggressive systemic mastocytosis, systemic mastocytosis with associated hematological neoplasm, or mast cell leukemia as a single therapy (FDA.gov).

DrugClasses CSF1R Inhibitor 23 FLT3 Inhibitor 54 KIT Inhibitor 50 PKC alpha Inhibitor 6 PKC beta Inhibitor 6 PKC Inhibitor (Pan) 10 VEGFR2 Inhibitor 35

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Azacitidine + Midostaurin Azacitidine Midostaurin 1 2
BMS-754807 + Midostaurin BMS-754807 Midostaurin 0 0
Bortezomib + Cytarabine + Etoposide + Midostaurin + Mitoxantrone Bortezomib Cytarabine Etoposide Midostaurin Mitoxantrone 1 0
CPX-351 + Midostaurin CPX-351 Midostaurin 0 1
Cytarabine + Daunorubicin + Gemtuzumab ozogamicin + Midostaurin Cytarabine Daunorubicin Gemtuzumab ozogamicin Midostaurin 0 0
Cytarabine + Daunorubicin + Midostaurin Cytarabine Daunorubicin Midostaurin 16 1
Cytarabine + Idarubicin + Midostaurin Cytarabine Idarubicin Midostaurin 0 1
Cytarabine + Midostaurin Cytarabine Midostaurin 0 1
Daunorubicin + Midostaurin Daunorubicin Midostaurin 0 1
Decitabine + Midostaurin Decitabine Midostaurin 0 2
Entospletinib + Midostaurin Entospletinib Midostaurin 1 0
Linsitinib + Midostaurin Linsitinib Midostaurin 0 0
Midostaurin Midostaurin 49 11
Midostaurin + PRT062607 Midostaurin PRT062607 3 0
Midostaurin + SCH772984 Midostaurin SCH772984 0 0


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