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Drug Name Melphalan
Trade Name Alkeran
Synonyms
Drug Descriptions

Alkeran (melphalan) is an antineoplastic alkylating agent, which cross-links DNA and induces cell toxicity and is FDA approved for multiple myeloma and epithelial ovarian carcinoma (FDA.gov).

DrugClasses Chemotherapy - Alkylating 14

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Therapy Name Drugs Efficacy Evidence Clinical Trials
90Y basiliximab + Basiliximab + Carmustine + Cytarabine + Etoposide + Melphalan 90Y basiliximab Basiliximab Carmustine Cytarabine Etoposide Melphalan 0 1
90Y basiliximab + Carmustine + Cytarabine + Etoposide + Melphalan 90Y basiliximab Carmustine Cytarabine Etoposide Melphalan 0 1
Aldesleukin + Melphalan + Sargramostim Aldesleukin Melphalan Sargramostim 0 1
ALT-803 + Elotuzumab + Melphalan ALT-803 Elotuzumab Melphalan 0 1
anti-thymocyte globulin + Cyclophosphamide + Filgrastim + Fludarabine + Melphalan + Mesna + Thiotepa Cyclophosphamide Filgrastim Fludarabine Melphalan Mesna Thiotepa anti-thymocyte globulin 0 1
anti-thymocyte globulin + Fludarabine + haNK cells + Melphalan Fludarabine Melphalan anti-thymocyte globulin haNK cells 0 1
anti-thymocyte globulin + Fludarabine + Melphalan Fludarabine Melphalan anti-thymocyte globulin 0 1
Bortezomib + Daratumumab + Dexamethasone + Melphalan + Prednisone Bortezomib Daratumumab Dexamethasone Melphalan Prednisone 0 1
Bortezomib + Daratumumab + Melphalan Bortezomib Daratumumab Melphalan 0 0
Bortezomib + Daratumumab + Melphalan + Prednisone Bortezomib Daratumumab Melphalan Prednisone 1 0
Bortezomib + Daratumumab and hyaluronidase-fihj + Melphalan + Prednisone Bortezomib Daratumumab and hyaluronidase-fihj Melphalan Prednisone 1 0
Bortezomib + Dexamethasone + Melphalan + Thalidomide Bortezomib Dexamethasone Melphalan Thalidomide 0 2
Bortezomib + Fludarabine + Melphalan Bortezomib Fludarabine Melphalan 0 1
Busulfan + Filgrastim + Fludarabine + Melphalan + MGTA-456 + Mycophenolate mofetil + Tacrolimus Busulfan Filgrastim Fludarabine MGTA-456 Melphalan Mycophenolate mofetil Tacrolimus 0 1
Busulfan + Gemcitabine + Melphalan + Panobinostat Busulfan Gemcitabine Melphalan Panobinostat 0 1
Busulfan + Melphalan Busulfan Melphalan 0 8
Carboplatin + Etoposide + Melphalan Carboplatin Etoposide Melphalan 0 1
Carboplatin + Etoposide + Melphalan + Vincristine Carboplatin Etoposide Melphalan Vincristine 0 1
Carboplatin + Melphalan Carboplatin Melphalan 0 1
Carmustine + CCR5 shRNA/TRIM5a/TAR decoy-transduced CD34+ HPCs + Cytarabine + Etoposide + Melphalan CCR5 shRNA/TRIM5a/TAR decoy-transduced CD34+ HPCs Carmustine Cytarabine Etoposide Melphalan 0 1
Carmustine + Cytarabine + Etoposide + Filgrastim + Lenalidomide + Melphalan + Rituximab Carmustine Cytarabine Etoposide Filgrastim Lenalidomide Melphalan Rituximab 0 1
Carmustine + Cytarabine + Etoposide + Melphalan Carmustine Cytarabine Etoposide Melphalan 0 5
Carmustine + Cytarabine + Etoposide + Melphalan + Rituximab Carmustine Cytarabine Etoposide Melphalan Rituximab 0 1
Carmustine + Cytarabine + Etoposide + Melphalan + Venetoclax Carmustine Cytarabine Etoposide Melphalan Venetoclax 0 2
CD45RA-depleted donor lymphocytes + Cyclophosphamide + Filgrastim + Fludarabine + Melphalan + Tacrolimus CD45RA-depleted donor lymphocytes Cyclophosphamide Filgrastim Fludarabine Melphalan Tacrolimus 0 0
Clofarabine + Melphalan Clofarabine Melphalan 0 1
Cyclophosphamide + Fludarabine + Melphalan + Sirolimus Cyclophosphamide Fludarabine Melphalan Sirolimus 0 1
Cyclophosphamide + Fludarabine + Melphalan + Tacrolimus Cyclophosphamide Fludarabine Melphalan Tacrolimus 0 1
Dactinomycin + Ipilimumab + Melphalan Dactinomycin Ipilimumab Melphalan 0 1
Dexamethasone + Melphalan + Selinexor Dexamethasone Melphalan Selinexor 0 1
Docetaxel + Gemcitabine + Melphalan Docetaxel Gemcitabine Melphalan 0 1
Etoposide + Melphalan Etoposide Melphalan 0 1
Fludarabine + inotuzumab ozogamicin + Melphalan + Tacrolimus Fludarabine Melphalan Tacrolimus inotuzumab ozogamicin 0 1
Fludarabine + Lenalidomide + Melphalan Fludarabine Lenalidomide Melphalan 0 1
Fludarabine + Melphalan Fludarabine Melphalan 0 10
Melphalan Melphalan 0 30
Melphalan + PVX-410 Melphalan PVX-410 0 1


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