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Drug Name Selinexor
Trade Name Xpovio
Synonyms KPT-330
Drug Descriptions

Xpovio (selinexor) inhibits CRM1 (XPO1), preventing CRM1-mediated nuclear export of tumor suppressor proteins and potentially restoring normal tumor suppressor function (PMID: 30976603, PMID: 31793336). Xpovio (selinexor) is FDA approved for use in combination with Adexone (dexamethasone) in patients with relapsed or refractory multiple myeloma (FDA.gov).

DrugClasses

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bortezomib + Dexamethasone + Selinexor Bortezomib Dexamethasone Selinexor 0 1
Carboplatin + Paclitaxel + Selinexor Carboplatin Paclitaxel Selinexor 0 1
Carfilzomib + Dexamethasone + Selinexor Carfilzomib Dexamethasone Selinexor 0 2
Carfilzomib + Selinexor Carfilzomib Selinexor 2 0
Cisplatin + Selinexor Cisplatin Selinexor 1 0
Cytarabine + Daunorubicin + Selinexor Cytarabine Daunorubicin Selinexor 0 1
Cytarabine + Fludarabine + Methotrexate + Prednisone + Selinexor Cytarabine Fludarabine Methotrexate Prednisone Selinexor 0 1
Decitabine + Selinexor Decitabine Selinexor 0 1
Dexamethasone + Ixazomib + Selinexor Dexamethasone Ixazomib Selinexor 0 1
Dexamethasone + Melphalan + Selinexor Dexamethasone Melphalan Selinexor 0 1
Dexamethasone + Pegylated liposomal-doxorubicin + Selinexor Dexamethasone Pegylated liposomal-doxorubicin Selinexor 1 1
Dexamethasone + Selinexor Dexamethasone Selinexor 1 2
Docetaxel + Selinexor Docetaxel Selinexor 0 1
Doxorubicin + Selinexor Doxorubicin Selinexor 1 1
Gemcitabine + Nab-paclitaxel + Selinexor Gemcitabine Nab-paclitaxel Selinexor 0 1
Ibrutinib + Selinexor Ibrutinib Selinexor 0 1
Irinotecan + Selinexor Irinotecan Selinexor 0 1
Ixazomib + Selinexor Ixazomib Selinexor 0 1
Selinexor Selinexor 6 29
Selinexor + Sorafenib Selinexor Sorafenib 4 1
Selinexor + Temozolomide Selinexor Temozolomide 0 1
Selinexor + Venetoclax Selinexor Venetoclax 0 1


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