Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Selinexor
Trade Name Xpovio
Synonyms KPT-330
Drug Descriptions

Xpovio (selinexor) inhibits CRM1 (XPO1), preventing CRM1-mediated nuclear export of tumor suppressor proteins and potentially restoring normal tumor suppressor function (PMID: 30976603, PMID: 31793336). Xpovio (selinexor) is FDA approved for use in patients with diffuse large B cell lymphoma after two or more prior therapies, in combination with Adexone (dexamethasone) in patients with relapsed or refractory multiple myeloma after at least four prior therapies, and in combination with Velcade (bortezomib) and Adexone (dexamethasone) in patients with multiple myeloma after at least one prior therapy (FDA.gov).

DrugClasses
CAS Registry Number 1393477-72-9
NCIT ID C102546

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Adagrasib + Selinexor Adagrasib Selinexor 0 0
Atezolizumab + Bevacizumab + Selinexor Atezolizumab Bevacizumab Selinexor 0 1
Atezolizumab + Selinexor Atezolizumab Selinexor 0 1
ATG-012 + Selinexor ATG-012 Selinexor 0 0
Bendamustine + Polatuzumab vedotin-piiq + Rituximab + Selinexor Bendamustine Polatuzumab vedotin-piiq Rituximab Selinexor 0 1
Bendamustine + Rituximab + Selinexor Bendamustine Rituximab Selinexor 0 1
Bortezomib + Daratumumab + Dexamethasone + Selinexor Bortezomib Daratumumab Dexamethasone Selinexor 0 2
Bortezomib + Daratumumab and hyaluronidase-fihj + Dexamethasone + Selinexor Bortezomib Daratumumab and hyaluronidase-fihj Dexamethasone Selinexor 0 1
Bortezomib + Dexamethasone + Selinexor Bortezomib Dexamethasone Selinexor 0 1
Carboplatin + Decitabine + Paclitaxel + Selinexor Carboplatin Decitabine Paclitaxel Selinexor 0 1
Carboplatin + Paclitaxel + Selinexor Carboplatin Paclitaxel Selinexor 0 1
Carfilzomib + Daratumumab + Dexamethasone + Selinexor Carfilzomib Daratumumab Dexamethasone Selinexor 0 1
Carfilzomib + Dexamethasone + Pomalidomide + Selinexor Carfilzomib Dexamethasone Pomalidomide Selinexor 0 1
Carfilzomib + Dexamethasone + Selinexor Carfilzomib Dexamethasone Selinexor 0 4
Carfilzomib + Selinexor Carfilzomib Selinexor 0 0
Choline salicylate + Selinexor Choline salicylate Selinexor 0 1
Cisplatin + Dexamethasone + Gemcitabine + Rituximab + Selinexor Cisplatin Dexamethasone Gemcitabine Rituximab Selinexor 0 1
Cisplatin + Selinexor Cisplatin Selinexor 0 0
Clarithromycin + Dexamethasone + Pomalidomide + Selinexor Clarithromycin Dexamethasone Pomalidomide Selinexor 0 1
Cytarabine + Daunorubicin + Selinexor Cytarabine Daunorubicin Selinexor 0 1
Cytarabine + Filgrastim + Fludarabine + Methotrexate + Selinexor + Venetoclax Cytarabine Filgrastim Fludarabine Methotrexate Selinexor Venetoclax 0 1
Cytarabine + Fludarabine + Methotrexate + Prednisone + Selinexor Cytarabine Fludarabine Methotrexate Prednisone Selinexor 0 1
Daratumumab + Dexamethasone + Lenalidomide + Selinexor Daratumumab Dexamethasone Lenalidomide Selinexor 0 1
Daratumumab + Dexamethasone + Selinexor Daratumumab Dexamethasone Selinexor 0 2
Decitabine + Selinexor Decitabine Selinexor 0 1
Dexamethasone + Ixazomib + Selinexor Dexamethasone Ixazomib Selinexor 0 1
Dexamethasone + Lenalidomide + Selinexor Dexamethasone Lenalidomide Selinexor 0 1
Dexamethasone + Melphalan + Selinexor Dexamethasone Melphalan Selinexor 0 1
Dexamethasone + Pegylated liposomal doxorubicin + Selinexor Dexamethasone Pegylated liposomal doxorubicin Selinexor 0 1
Dexamethasone + Pomalidomide + Selinexor Dexamethasone Pomalidomide Selinexor 0 4
Dexamethasone + Selinexor Dexamethasone Selinexor 0 2
Dexamethasone + Selinexor + Venetoclax Dexamethasone Selinexor Venetoclax 0 1
Docetaxel + Selinexor Docetaxel Selinexor 0 1
Doxorubicin + Selinexor Doxorubicin Selinexor 0 1
Gemcitabine + Nab-paclitaxel + Selinexor Gemcitabine Nab-paclitaxel Selinexor 0 1
Gemcitabine + Oxaliplatin + Rituximab + Selinexor Gemcitabine Oxaliplatin Rituximab Selinexor 0 1
Gemcitabine + Selinexor Gemcitabine Selinexor 0 1
Ibrutinib + Rituximab + Selinexor Ibrutinib Rituximab Selinexor 0 1
Ibrutinib + Selinexor Ibrutinib Selinexor 0 1
Idasanutlin + Selinexor Idasanutlin Selinexor 0 1
Imatinib + Selinexor Imatinib Selinexor 0 1
Irinotecan + Selinexor Irinotecan Selinexor 0 1
Ixazomib + Selinexor Ixazomib Selinexor 0 1
Lenalidomide + Rituximab + Selinexor Lenalidomide Rituximab Selinexor 0 1
Lenalidomide + Selinexor Lenalidomide Selinexor 0 2
Lenalidomide + Selinexor + Tafasitamab-cxix Lenalidomide Selinexor Tafasitamab-cxix 0 1
Lomustine + Selinexor Lomustine Selinexor 0 1
MRTX1257 + Selinexor MRTX1257 Selinexor 0 0
Pembrolizumab + Selinexor Pembrolizumab Selinexor 0 3
Polatuzumab vedotin-piiq + Rituximab + Selinexor Polatuzumab vedotin-piiq Rituximab Selinexor 0 1
Ruxolitinib + Selinexor Ruxolitinib Selinexor 0 1
Selinexor Selinexor 2 38
Selinexor + Sorafenib Selinexor Sorafenib 4 1
Selinexor + Sotorasib Selinexor Sotorasib 0 0
Selinexor + Temozolomide Selinexor Temozolomide 0 3
Selinexor + Venetoclax Selinexor Venetoclax 0 2


Additional content available in CKB BOOST