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Drug Name Selinexor
Trade Name Xpovio
Synonyms KPT-330
Drug Descriptions

Xpovio (selinexor) inhibits CRM1 (XPO1), preventing CRM1-mediated nuclear export of tumor suppressor proteins and potentially restoring normal tumor suppressor function (PMID: 30976603, PMID: 31793336). Xpovio (selinexor) is FDA approved for use in patients with diffuse large B cell lymphoma after two or more prior therapies, in combination with Adexone (dexamethasone) in patients with relapsed or refractory multiple myeloma after at least four prior therapies, and in combination with Velcade (bortezomib) and Adexone (dexamethasone) in patients with multiple myeloma after at least one prior therapy (FDA.gov).

DrugClasses
CAS Registry Number 1393477-72-9
NCIT ID C102546

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bendamustine + Polatuzumab vedotin-piiq + Rituximab + Selinexor Bendamustine Polatuzumab vedotin-piiq Rituximab Selinexor 0 1
Bendamustine + Rituximab + Selinexor Bendamustine Rituximab Selinexor 0 1
Bortezomib + Dexamethasone + Selinexor Bortezomib Dexamethasone Selinexor 1 1
Carboplatin + Paclitaxel + Selinexor Carboplatin Paclitaxel Selinexor 0 1
Carfilzomib + Daratumumab + Dexamethasone + Selinexor Carfilzomib Daratumumab Dexamethasone Selinexor 0 1
Carfilzomib + Dexamethasone + Pomalidomide + Selinexor Carfilzomib Dexamethasone Pomalidomide Selinexor 0 1
Carfilzomib + Dexamethasone + Selinexor Carfilzomib Dexamethasone Selinexor 0 3
Carfilzomib + Selinexor Carfilzomib Selinexor 2 0
Choline salicylate + Selinexor Choline salicylate Selinexor 0 1
Cisplatin + Dexamethasone + Gemcitabine + Rituximab + Selinexor Cisplatin Dexamethasone Gemcitabine Rituximab Selinexor 0 1
Cisplatin + Selinexor Cisplatin Selinexor 1 0
Cytarabine + Daunorubicin + Selinexor Cytarabine Daunorubicin Selinexor 0 1
Cytarabine + Fludarabine + Methotrexate + Prednisone + Selinexor Cytarabine Fludarabine Methotrexate Prednisone Selinexor 0 1
Daratumumab + Dexamethasone + Lenalidomide + Selinexor Daratumumab Dexamethasone Lenalidomide Selinexor 0 1
Daratumumab + Dexamethasone + Selinexor Daratumumab Dexamethasone Selinexor 0 1
Decitabine + Selinexor Decitabine Selinexor 0 1
Dexamethasone + Ixazomib + Selinexor Dexamethasone Ixazomib Selinexor 0 1
Dexamethasone + Melphalan + Selinexor Dexamethasone Melphalan Selinexor 0 1
Dexamethasone + Pegylated liposomal-doxorubicin + Selinexor Dexamethasone Pegylated liposomal-doxorubicin Selinexor 1 1
Dexamethasone + Pomalidomide + Selinexor Dexamethasone Pomalidomide Selinexor 0 2
Dexamethasone + Selinexor Dexamethasone Selinexor 1 2
Docetaxel + Selinexor Docetaxel Selinexor 0 1
Doxorubicin + Selinexor Doxorubicin Selinexor 1 1
Gemcitabine + Nab-paclitaxel + Selinexor Gemcitabine Nab-paclitaxel Selinexor 0 1
Gemcitabine + Oxaliplatin + Rituximab + Selinexor Gemcitabine Oxaliplatin Rituximab Selinexor 0 1
Ibrutinib + Rituximab + Selinexor Ibrutinib Rituximab Selinexor 0 1
Ibrutinib + Selinexor Ibrutinib Selinexor 0 1
Irinotecan + Selinexor Irinotecan Selinexor 0 1
Ixazomib + Selinexor Ixazomib Selinexor 0 1
Lenalidomide + Rituximab + Selinexor Lenalidomide Rituximab Selinexor 0 1
Lenalidomide + Selinexor Lenalidomide Selinexor 0 1
Lenalidomide + Selinexor + Tafasitamab-cxix Lenalidomide Selinexor Tafasitamab-cxix 0 1
Lomustine + Selinexor Lomustine Selinexor 0 1
Polatuzumab vedotin-piiq + Rituximab + Selinexor Polatuzumab vedotin-piiq Rituximab Selinexor 0 1
Selinexor Selinexor 8 31
Selinexor + Sorafenib Selinexor Sorafenib 4 1
Selinexor + Temozolomide Selinexor Temozolomide 0 2
Selinexor + Venetoclax Selinexor Venetoclax 0 2


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