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|Therapy Name||MRTX1257 + Selinexor|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|MRTX1257||MRTX-1257|MRTX 1257||KRAS G12C inhibitor 32||MRTX1257 selectively inhibits KRAS G12C, which may lead to growth inhibition in tumor cells harboring KRAS G12C (AACR Annual Meeting 2019, Abstract LB-271).|
|Selinexor||Xpovio||KPT-330||Xpovio (selinexor) inhibits CRM1 (XPO1), preventing CRM1-mediated nuclear export of tumor suppressor proteins and potentially restoring normal tumor suppressor function (PMID: 30976603, PMID: 31793336). Xpovio (selinexor) is FDA approved for use in patients with diffuse large B cell lymphoma after two or more prior therapies, in combination with Adexone (dexamethasone) in patients with relapsed or refractory multiple myeloma after at least four prior therapies, and in combination with Velcade (bortezomib) and Adexone (dexamethasone) in patients with multiple myeloma after at least one prior therapy (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|