Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Idasanutlin
Trade Name
Synonyms RO-5503781|RO 5503781|RO5503781|RG7388|RG-7388
Drug Descriptions

Idasanutlin (RG7388) binds to MDM2 to block subsequent interaction with p53, which prevents degradation of p53, thereby resulting in restoration of wild-type p53 activity and potentially promoting apoptosis of tumor cells (PMID: 23808545, PMID: 32338053, PMID: 32020437).

DrugClasses MDM2 Inhibitor 19

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + Idasanutlin Atezolizumab Idasanutlin 0 1
Cyclophosphamide + Idasanutlin Cyclophosphamide Idasanutlin 0 1
Cyclophosphamide + Idasanutlin + Topotecan Cyclophosphamide Idasanutlin Topotecan 0 1
Cytarabine + Daunorubicin + Idasanutlin Cytarabine Daunorubicin Idasanutlin 0 1
Cytarabine + Fludarabine + Idasanutlin Cytarabine Fludarabine Idasanutlin 0 1
Cytarabine + Hydrocortisone + Idasanutlin + Methotrexate + Venetoclax Cytarabine Hydrocortisone Idasanutlin Methotrexate Venetoclax 0 0
Cytarabine + Idasanutlin Cytarabine Idasanutlin 0 2
Cytarabine + Idasanutlin + Venetoclax Cytarabine Idasanutlin Venetoclax 0 0
Dexamethasone + Idasanutlin + Ixazomib Dexamethasone Idasanutlin Ixazomib 0 1
Doxorubicin + Idasanutlin Doxorubicin Idasanutlin 0 0
Fludarabine + Idasanutlin Fludarabine Idasanutlin 0 0
GSK2830371 + Idasanutlin GSK2830371 Idasanutlin 0 0
Idasanutlin Idasanutlin 0 4
Idasanutlin + Methotrexate + Venetoclax Idasanutlin Methotrexate Venetoclax 0 0
Idasanutlin + Obinutuzumab Idasanutlin Obinutuzumab 0 1
Idasanutlin + Obinutuzumab + Rituximab + Venetoclax Idasanutlin Obinutuzumab Rituximab Venetoclax 0 1
Idasanutlin + Obinutuzumab + Venetoclax Idasanutlin Obinutuzumab Venetoclax 0 1
Idasanutlin + Rituximab + Venetoclax Idasanutlin Rituximab Venetoclax 0 1
Idasanutlin + Topotecan Idasanutlin Topotecan 0 0
Idasanutlin + Venetoclax Idasanutlin Venetoclax 0 2


Additional content available in CKB BOOST