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Drug Name Topotecan
Trade Name Hycamtin
Synonyms Topotecan Hcl
Drug Descriptions

Topotecan binds to topoisomerase I and stablizes complexes with DNA, resulting in decreased repair of DNA single-strand breaks, and potentially leading to cell death (NCI Drug Dictionary).

DrugClasses
CAS Registry Number 119413-54-6
NCIT ID C2828

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Therapy Name Drugs Efficacy Evidence Clinical Trials
A-966492 + Radiotherapy + Topotecan A-966492 Radiotherapy Topotecan 0 0
AC480 + Topotecan AC480 Topotecan 0 0
AG-14361 + Topotecan AG-14361 Topotecan 0 0
ALRN-6924 + Topotecan ALRN-6924 Topotecan 0 1
BAY1895344 + Topotecan BAY1895344 Topotecan 0 1
Berzosertib + Topotecan Berzosertib Topotecan 0 2
Bevacizumab + Cyclophosphamide + Topotecan Bevacizumab Cyclophosphamide Topotecan 0 1
Bevacizumab + Paclitaxel + Topotecan Bevacizumab Paclitaxel Topotecan 0 0
Bevacizumab + Temozolomide + Topotecan Bevacizumab Temozolomide Topotecan 0 1
Bevacizumab + Topotecan Bevacizumab Topotecan 0 2
Bortezomib + Temsirolimus + Topotecan Bortezomib Temsirolimus Topotecan 1 0
Cabozantinib + Cyclophosphamide + Filgrastim + Topotecan Cabozantinib Cyclophosphamide Filgrastim Topotecan 0 1
Cabozantinib + Cyclophosphamide + Pegfilgrastim + Topotecan Cabozantinib Cyclophosphamide Pegfilgrastim Topotecan 0 1
Carboplatin + Topotecan Carboplatin Topotecan 0 2
Carboplatin + Topotecan + Veliparib Carboplatin Topotecan Veliparib 0 1
Crizotinib + Cyclophosphamide + Topotecan Crizotinib Cyclophosphamide Topotecan 12 0
Cyclophosphamide + Dinutuximab beta + Topotecan Cyclophosphamide Dinutuximab beta Topotecan 0 1
Cyclophosphamide + Erlotinib + Topotecan Cyclophosphamide Erlotinib Topotecan 0 1
Cyclophosphamide + Etoposide + Topotecan Cyclophosphamide Etoposide Topotecan 0 1
Cyclophosphamide + Filgrastim + Simvastatin + Topotecan Cyclophosphamide Filgrastim Simvastatin Topotecan 0 1
Cyclophosphamide + Idasanutlin + Topotecan Cyclophosphamide Idasanutlin Topotecan 0 1
Cyclophosphamide + Lorlatinib + Topotecan Cyclophosphamide Lorlatinib Topotecan 0 1
Cyclophosphamide + LY3295668 + Topotecan Cyclophosphamide LY3295668 Topotecan 0 1
Cyclophosphamide + Nifurtimox + Topotecan Cyclophosphamide Nifurtimox Topotecan 0 1
Cyclophosphamide + SGT-53 + Topotecan Cyclophosphamide SGT-53 Topotecan 0 1
Cyclophosphamide + Sirolimus + Topotecan Cyclophosphamide Sirolimus Topotecan 0 1
Cyclophosphamide + Sorafenib + Topotecan Cyclophosphamide Sorafenib Topotecan 0 1
Cyclophosphamide + Topotecan Cyclophosphamide Topotecan 0 6
Cyclophosphamide + Topotecan + Venetoclax Cyclophosphamide Topotecan Venetoclax 0 0
Dinutuximab beta + Temozolomide + Topotecan Dinutuximab beta Temozolomide Topotecan 0 1
Durvalumab + Topotecan Durvalumab Topotecan 0 1
GSK2256098 + Topotecan GSK2256098 Topotecan 1 0
HM30181A + Topotecan HM30181A Topotecan 0 1
Idasanutlin + Topotecan Idasanutlin Topotecan 0 0
Iniparib + Topotecan Iniparib Topotecan 0 1
LCL161 + Topotecan LCL161 Topotecan 0 1
M7824 + Topotecan M7824 Topotecan 0 1
ME-344 + Topotecan ME-344 Topotecan 0 1
MEDI5117 + Topotecan MEDI5117 Topotecan 0 0
Paclitaxel + Pegylated liposomal-doxorubicin + Topotecan Paclitaxel Pegylated liposomal-doxorubicin Topotecan 0 2
Pazopanib + Topotecan Pazopanib Topotecan 0 5
Pegfilgrastim + Tivantinib + Topotecan Pegfilgrastim Tivantinib Topotecan 0 1
Pembrolizumab + Topotecan Pembrolizumab Topotecan 0 1
PV1019 + Topotecan PV1019 Topotecan 0 0
Ribociclib + Temozolomide + Topotecan Ribociclib Temozolomide Topotecan 0 1
Rucaparib + Topotecan Rucaparib Topotecan 0 0
Sorafenib + Topotecan Sorafenib Topotecan 0 1
Temozolomide + Topotecan Temozolomide Topotecan 0 1
Topotecan Topotecan 0 22
Topotecan + Trilaciclib Topotecan Trilaciclib 1 0
Topotecan + Veliparib Topotecan Veliparib 0 2
Topotecan + Vincristine Sulfate Topotecan Vincristine Sulfate 0 1
Topotecan + VX-803 Topotecan VX-803 0 0


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