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Drug Name Topotecan
Trade Name Hycamtin
Synonyms Topotecan Hcl
Drug Descriptions

Topotecan binds to topoisomerase I and stablizes complexes with DNA, resulting in decreased repair of DNA single-strand breaks, and potentially leading to cell death (NCI Drug Dictionary).

DrugClasses

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Therapy Name Drugs Efficacy Evidence Clinical Trials
A-966492 + Radiotherapy + Topotecan A-966492 Radiotherapy Topotecan 1 0
AG-14361 + Topotecan AG-14361 Topotecan 0 0
Berzosertib + Topotecan Berzosertib Topotecan 0 1
Bevacizumab + Cyclophosphamide + Topotecan Bevacizumab Cyclophosphamide Topotecan 0 1
Bevacizumab + Paclitaxel + Topotecan Bevacizumab Paclitaxel Topotecan 1 0
Bortezomib + Temsirolimus + Topotecan Bortezomib Temsirolimus Topotecan 1 0
Carboplatin + Topotecan Carboplatin Topotecan 0 2
Carboplatin + Topotecan + Veliparib Carboplatin Topotecan Veliparib 2 1
Crizotinib + Cyclophosphamide + Topotecan Crizotinib Cyclophosphamide Topotecan 1 0
Cyclophosphamide + Erlotinib + Topotecan Cyclophosphamide Erlotinib Topotecan 0 1
Cyclophosphamide + Etoposide + Topotecan Cyclophosphamide Etoposide Topotecan 0 1
Cyclophosphamide + Filgrastim + Simvastatin + Topotecan Cyclophosphamide Filgrastim Simvastatin Topotecan 0 1
Cyclophosphamide + Idasanutlin + Topotecan Cyclophosphamide Idasanutlin Topotecan 0 1
Cyclophosphamide + Lorlatinib + Topotecan Cyclophosphamide Lorlatinib Topotecan 0 1
Cyclophosphamide + LY3295668 + Topotecan Cyclophosphamide LY3295668 Topotecan 0 1
Cyclophosphamide + Nifurtimox + Topotecan Cyclophosphamide Nifurtimox Topotecan 0 1
Cyclophosphamide + SGT-53 + Topotecan Cyclophosphamide SGT-53 Topotecan 0 1
Cyclophosphamide + Sirolimus + Topotecan Cyclophosphamide Sirolimus Topotecan 0 1
Cyclophosphamide + Sorafenib + Topotecan Cyclophosphamide Sorafenib Topotecan 0 1
Cyclophosphamide + Topotecan Cyclophosphamide Topotecan 1 6
GSK2256098 + Topotecan GSK2256098 Topotecan 0 0
HM30181A + Topotecan HM30181A Topotecan 0 1
Idasanutlin + Topotecan Idasanutlin Topotecan 0 0
Iniparib + Topotecan Iniparib Topotecan 0 1
LCL161 + Topotecan LCL161 Topotecan 0 1
M7824 + Topotecan M7824 Topotecan 0 1
ME-344 + Topotecan ME-344 Topotecan 0 1
MEDI5117 + Topotecan MEDI5117 Topotecan 0 0
Pazopanib + Topotecan Pazopanib Topotecan 0 5
Pegfilgrastim + Tivantinib + Topotecan Pegfilgrastim Tivantinib Topotecan 0 1
Pembrolizumab + Topotecan Pembrolizumab Topotecan 0 1
PV1019 + Topotecan PV1019 Topotecan 1 0
Rucaparib + Topotecan Rucaparib Topotecan 0 0
Sorafenib + Topotecan Sorafenib Topotecan 0 1
Topotecan Topotecan 1 17
Topotecan + Trilaciclib Topotecan Trilaciclib 1 0
Topotecan + Veliparib Topotecan Veliparib 2 1
Topotecan + Vincristine Sulfate Topotecan Vincristine Sulfate 0 1


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