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Drug Name M7824
Trade Name
Synonyms Bintrafusp alfa|MSB0011359C
Drug Descriptions

Bintrafusp alfa (M7824) is a human PD-L1 (CD274) antibody fused with transforming growth factor-beta (TGF-beta, TGFBR2) receptor II extracellular domain, which blocks two immuno-inhibitory pathways simultaneously, therefore enhances anti-tumor immunity (PMID: 29298798).

DrugClasses Immune Checkpoint Inhibitor 95 PD-L1/PD-1 antibody 62 TGFBR2 Antibody 2

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Ado-trastuzumab emtansine + Entinostat + FPV-Brachyury + M7824 + MVA-BN-Brachyury Ado-trastuzumab emtansine Entinostat FPV-Brachyury M7824 MVA-BN-Brachyury 0 1
Ado-trastuzumab emtansine + FPV-Brachyury + M7824 + MVA-BN-Brachyury Ado-trastuzumab emtansine FPV-Brachyury M7824 MVA-BN-Brachyury 0 1
ALT-803 + Epacadostat + FPV-Brachyury + M7824 + MVA-BN-Brachyury ALT-803 Epacadostat FPV-Brachyury M7824 MVA-BN-Brachyury 0 1
ALT-803 + ETBX-011 + ETBX-051 + ETBX-061 + M7824 ALT-803 ETBX-011 ETBX-051 ETBX-061 M7824 0 1
ALT-803 + FPV-Brachyury + M7824 + MVA-BN-Brachyury ALT-803 FPV-Brachyury M7824 MVA-BN-Brachyury 0 1
ALT-803 + M7824 ALT-803 M7824 0 1
Carboplatin + Gemcitabine + M7824 Carboplatin Gemcitabine M7824 0 1
Carboplatin + M7824 + Nab-paclitaxel Carboplatin M7824 Nab-paclitaxel 0 1
Carboplatin + M7824 + Paclitaxel Carboplatin M7824 Paclitaxel 0 1
Carboplatin + M7824 + Pemetrexed Carboplatin M7824 Pemetrexed 0 1
Cisplatin + Etoposide + M7824 Cisplatin Etoposide M7824 0 1
Cisplatin + Gemcitabine + M7824 Cisplatin Gemcitabine M7824 0 2
Cisplatin + M7824 + Pemetrexed Cisplatin M7824 Pemetrexed 0 2
CV301 + M7824 + PROSTVAC-F/TRICOM + PROSTVAC-V/TRICOM CV301 M7824 PROSTVAC-F/TRICOM PROSTVAC-V/TRICOM 0 1
Docetaxel + M7824 Docetaxel M7824 0 2
Eribulin + M7824 Eribulin M7824 0 1
ETBX-011 + ETBX-051 + ETBX-061 + M7824 ETBX-011 ETBX-051 ETBX-061 M7824 0 1
FPV-Brachyury + M7824 + MVA-BN-Brachyury FPV-Brachyury M7824 MVA-BN-Brachyury 0 2
Gemcitabine + M7824 Gemcitabine M7824 0 1
M7824 M7824 0 13
M7824 + NHS-IL12 M7824 NHS-IL12 0 3
M7824 + NHS-IL12 + PDS0101 M7824 NHS-IL12 PDS0101 0 1
M7824 + Temozolomide M7824 Temozolomide 0 1
M7824 + Topotecan M7824 Topotecan 0 1


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