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Drug Name Bintrafusp alfa
Trade Name
Synonyms MSB0011359C|M7824
Drug Descriptions

Bintrafusp alfa is a human PD-L1 (CD274) antibody fused with transforming growth factor-beta (TGF-beta, TGFBR2) receptor II extracellular domain, which blocks two immuno-inhibitory pathways simultaneously, therefore enhances anti-tumor immunity (PMID: 29298798, PMID: 32461347).

DrugClasses Immune Checkpoint Inhibitor 151 PD-L1/PD-1 antibody 98 TGFBR2 Antibody 2
CAS Registry Number 1918149-01-5
NCIT ID C124229

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Ado-trastuzumab emtansine + Bintrafusp alfa + Entinostat + FPV-Brachyury + MVA-BN-Brachyury Ado-trastuzumab emtansine Bintrafusp alfa Entinostat FPV-Brachyury MVA-BN-Brachyury 0 1
Ado-trastuzumab emtansine + Bintrafusp alfa + FPV-Brachyury + MVA-BN-Brachyury Ado-trastuzumab emtansine Bintrafusp alfa FPV-Brachyury MVA-BN-Brachyury 0 1
ALT-803 + Bintrafusp alfa ALT-803 Bintrafusp alfa 0 2
ALT-803 + Bintrafusp alfa + CV301 ALT-803 Bintrafusp alfa CV301 0 1
ALT-803 + Bintrafusp alfa + CV301 + NHS-IL12 ALT-803 Bintrafusp alfa CV301 NHS-IL12 0 1
ALT-803 + Bintrafusp alfa + Epacadostat + FPV-Brachyury + MVA-BN-Brachyury ALT-803 Bintrafusp alfa Epacadostat FPV-Brachyury MVA-BN-Brachyury 0 1
ALT-803 + Bintrafusp alfa + ETBX-011 + ETBX-051 + ETBX-061 ALT-803 Bintrafusp alfa ETBX-011 ETBX-051 ETBX-061 0 1
ALT-803 + Bintrafusp alfa + FPV-Brachyury + MVA-BN-Brachyury ALT-803 Bintrafusp alfa FPV-Brachyury MVA-BN-Brachyury 0 1
Azacitidine + Bintrafusp alfa Azacitidine Bintrafusp alfa 0 1
Bevacizumab + Bintrafusp alfa + Carboplatin + Paclitaxel Bevacizumab Bintrafusp alfa Carboplatin Paclitaxel 0 1
Bevacizumab + Bintrafusp alfa + Cisplatin + Paclitaxel Bevacizumab Bintrafusp alfa Cisplatin Paclitaxel 0 1
Bintrafusp alfa Bintrafusp alfa 0 22
Bintrafusp alfa + Carboplatin + Gemcitabine Bintrafusp alfa Carboplatin Gemcitabine 0 1
Bintrafusp alfa + Carboplatin + Nab-paclitaxel Bintrafusp alfa Carboplatin Nab-paclitaxel 0 1
Bintrafusp alfa + Carboplatin + Paclitaxel Bintrafusp alfa Carboplatin Paclitaxel 0 3
Bintrafusp alfa + Carboplatin + Pemetrexed Disodium Bintrafusp alfa Carboplatin Pemetrexed Disodium 0 2
Bintrafusp alfa + Cisplatin Bintrafusp alfa Cisplatin 0 1
Bintrafusp alfa + Cisplatin + Etoposide Bintrafusp alfa Cisplatin Etoposide 0 1
Bintrafusp alfa + Cisplatin + Gemcitabine Bintrafusp alfa Cisplatin Gemcitabine 0 2
Bintrafusp alfa + Cisplatin + Paclitaxel Bintrafusp alfa Cisplatin Paclitaxel 0 1
Bintrafusp alfa + Cisplatin + Pemetrexed Disodium Bintrafusp alfa Cisplatin Pemetrexed Disodium 0 3
Bintrafusp alfa + CV301 + PROSTVAC-F-TRICOM + PROSTVAC-V-TRICOM Bintrafusp alfa CV301 PROSTVAC-F-TRICOM PROSTVAC-V-TRICOM 0 1
Bintrafusp alfa + CV301 + SX-682 Bintrafusp alfa CV301 SX-682 0 0
Bintrafusp alfa + Degarelix + Docetaxel + NHS-IL12 + Prednisone Bintrafusp alfa Degarelix Docetaxel NHS-IL12 Prednisone 0 1
Bintrafusp alfa + Docetaxel Bintrafusp alfa Docetaxel 0 2
Bintrafusp alfa + Docetaxel + NHS-IL12 Bintrafusp alfa Docetaxel NHS-IL12 0 1
Bintrafusp alfa + Doxorubicin Bintrafusp alfa Doxorubicin 0 1
Bintrafusp alfa + Entinostat + NHS-IL12 Bintrafusp alfa Entinostat NHS-IL12 0 1
Bintrafusp alfa + Eribulin Bintrafusp alfa Eribulin 0 1
Bintrafusp alfa + ETBX-011 + ETBX-051 + ETBX-061 Bintrafusp alfa ETBX-011 ETBX-051 ETBX-061 0 1
Bintrafusp alfa + FPV-Brachyury + MVA-BN-Brachyury Bintrafusp alfa FPV-Brachyury MVA-BN-Brachyury 0 2
Bintrafusp alfa + FPV-CV301 + MVA-BN-CV301 + SX-682 Bintrafusp alfa FPV-CV301 MVA-BN-CV301 SX-682 0 1
Bintrafusp alfa + Gemcitabine Bintrafusp alfa Gemcitabine 0 1
Bintrafusp alfa + M6223 Bintrafusp alfa M6223 0 1
Bintrafusp alfa + NHS-IL12 Bintrafusp alfa NHS-IL12 0 4
Bintrafusp alfa + NHS-IL12 + PDS0101 Bintrafusp alfa NHS-IL12 PDS0101 0 1
Bintrafusp alfa + Pimasertib Bintrafusp alfa Pimasertib 0 1
Bintrafusp alfa + PRGN-2009 Bintrafusp alfa PRGN-2009 0 1
Bintrafusp alfa + Radiotherapy Bintrafusp alfa Radiotherapy 0 1
Bintrafusp alfa + Temozolomide Bintrafusp alfa Temozolomide 0 1
Bintrafusp alfa + Topotecan Bintrafusp alfa Topotecan 0 1


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