Therapy Detail

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Therapy Name Bintrafusp alfa + NHS-IL12 + PDS0101
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Bintrafusp alfa MSB0011359C|M7824 Immune Checkpoint Inhibitor 147 PD-L1/PD-1 antibody 117 TGFBR2 Antibody 3 Bintrafusp alfa is a human PD-L1 (CD274) antibody fused with transforming growth factor-beta (TGF-beta, TGFBR2) receptor II extracellular domain, which blocks two immuno-inhibitory pathways simultaneously, therefore enhances anti-tumor immunity (PMID: 29298798, PMID: 32461347).
NHS-IL12 M9241|M-9241 NHS-IL12 (M9241) is an immunocytokine composed of IL-12 linked to human tumor necrosis factor targeted IgG1, which may result in enhanced anti-tumor immune response (PMID: 24681847).
PDS0101 PDS 0101|PDS-0101 PDS0101 is a cancer vaccine comprising 6 HPV-16 E6 and E7 peptides encapsulated in a lipid nanoparticle, which potentially stimulates anti-tumor immune response (PMID: 32554612).

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04287868 Phase Ib/II Bintrafusp alfa + NHS-IL12 + PDS0101 Combination Immunotherapy in Subjects With Advanced HPV Associated Malignancies Active, not recruiting USA 0


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