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Therapy Name | Cisplatin + M7824 |
Synonyms | |
Therapy Description | |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
Cisplatin | Platinol | CDDP | Chemotherapy - Platinum 7 | Platinol (cisplatin) is a platinum based chemotherapeutic, which is FDA approved for bladder, ovarian, and testicular cancers (NCI Drug Dictionary). |
M7824 | Bintrafusp alfa|MSB0011359C | Immune Checkpoint Inhibitor 147 PD-L1/PD-1 antibody 89 TGFBR2 Antibody 2 | Bintrafusp alfa (M7824) is a human PD-L1 (CD274) antibody fused with transforming growth factor-beta (TGF-beta, TGFBR2) receptor II extracellular domain, which blocks two immuno-inhibitory pathways simultaneously, therefore enhances anti-tumor immunity (PMID: 29298798, PMID: 32461347). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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NCT04551950 | Phase I | Bevacizumab + Carboplatin + M7824 + Paclitaxel Bevacizumab + Cisplatin + M7824 + Paclitaxel Cisplatin + M7824 + Paclitaxel Cisplatin + M7824 Carboplatin + M7824 + Paclitaxel | Bintrafusp Alfa Combination Therapy in Participants With Cervical Cancer (INTRAPID 046) | Active, not recruiting | USA | ESP | 1 |