Therapy Detail

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Therapy Name ALT-803 + Bintrafusp alfa + CV301 + NHS-IL12
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ALT-803 N-803|N803|N 803|nogapendekin alfa|ALT803|ALT 803 ALT-803 (nogapendekin alfa) is a fusion protein comprising a mutant version of IL-15 with increased activity and IL-15Ra fused to the Fc region of IgG1, which activates CD8+ T-cells and promotes effector activity, potentially resulting in increased antitumor immune response (PMID: 24404427, PMID: 31338557).
Bintrafusp alfa MSB0011359C|M7824 Immune Checkpoint Inhibitor 146 PD-L1/PD-1 antibody 107 TGFBR2 Antibody 2 Bintrafusp alfa is a human PD-L1 (CD274) antibody fused with transforming growth factor-beta (TGF-beta, TGFBR2) receptor II extracellular domain, which blocks two immuno-inhibitory pathways simultaneously, therefore enhances anti-tumor immunity (PMID: 29298798, PMID: 32461347).
CV301 CV-301|PANVAC|CV301-V/F|BN-CV301 CV301 is a poxvirus-based vaccine that encodes tumor antigens CEA and MUC-1, and 3 costimulatory molecules including B7.1, ICAM-1, and LFA-3, which may stimulate antitumor immune response (PMID: 31110074).
NHS-IL12 M9241|M-9241 NHS-IL12 (M9241) is an immunocytokine composed of IL-12 linked to human tumor necrosis factor targeted IgG1, which may result in enhanced anti-tumor immune response (PMID: 24681847).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04491955 Phase II ALT-803 + Bintrafusp alfa + CV301 + NHS-IL12 ALT-803 + Bintrafusp alfa + CV301 Phase II Trial of Combination Immunotherapy in Subjects With Advanced Small Bowel and Colorectal Cancers Completed USA 0


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