Therapy Detail

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Therapy Name ALT-803 + Bintrafusp alfa
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ALT-803 N-803|N803|N 803|nogapendekin alfa|ALT803|ALT 803 ALT-803 (nogapendekin alfa) is a fusion protein comprising a mutant version of IL-15 with increased activity and IL-15Ra fused to the Fc region of IgG1, which activates CD8+ T-cells and promotes effector activity, potentially resulting in increased antitumor immune response (PMID: 24404427, PMID: 31338557).
Bintrafusp alfa MSB0011359C|M7824 Immune Checkpoint Inhibitor 147 PD-L1/PD-1 antibody 117 TGFBR2 Antibody 3 Bintrafusp alfa is a human PD-L1 (CD274) antibody fused with transforming growth factor-beta (TGF-beta, TGFBR2) receptor II extracellular domain, which blocks two immuno-inhibitory pathways simultaneously, therefore enhances anti-tumor immunity (PMID: 29298798, PMID: 32461347).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03493945 Phase Ib/II ALT-803 + Bintrafusp alfa + Epacadostat + FPV-Brachyury + MVA-BN-Brachyury Bintrafusp alfa + FPV-Brachyury + MVA-BN-Brachyury ALT-803 + Bintrafusp alfa + FPV-Brachyury + MVA-BN-Brachyury ALT-803 + Bintrafusp alfa Phase I/II Study of Immunotherapy Combination BN-Brachyury Vaccine, M7824, ALT-803 and Epacadostat (QuEST1). Recruiting USA 0
NCT05445882 Phase II ALT-803 + Bintrafusp alfa ALT-803 N-803 Alone or in Combination With BN-Brachyury Vaccine or Bintrafusp Alfa (M7824) for Participants With Castration Resistant Prostate Cancer Not yet recruiting USA 0


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