Therapy Detail

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Therapy Name ALT-803 + FPV-Brachyury + M7824 + MVA-BN-Brachyury
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ALT-803 N-803|N803 ALT-803 is a fusion protein consisting a mutant IL-15 and a soluble IL-15Ra Fc, which activates and converts memory CD8+ T cells to effector immune cells with antitumor activity (PMID: 24404427).
FPV-Brachyury FPV-Brachyury-TRICOM Vaccine FPV-Brachyury is a putative vaccine that infects cells and induces expression of the brachyury protein protein to elicit an immune response (Journal of Clinical Oncology 37, no. 15_suppl (May 20, 2019) 2640-2640).
M7824 Bintrafusp alfa|MSB0011359C Immune Checkpoint Inhibitor 94 PD-L1/PD-1 antibody 63 TGFBR2 Antibody 2 Bintrafusp alfa (M7824) is a human PD-L1 (CD274) antibody fused with transforming growth factor-beta (TGF-beta, TGFBR2) receptor II extracellular domain, which blocks two immuno-inhibitory pathways simultaneously, therefore enhances anti-tumor immunity (PMID: 29298798, PMID: 32461347).
MVA-BN-Brachyury MVA-BN-Brachyury is a poxvirus-based immunotherapy that targets Brachyury-expressing tumor cells (Journal of Clinical Oncology 33, no. 15_suppl (May 20 2015) 3079-3079).

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  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
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  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status
NCT03493945 Phase Ib/II ALT-803 + Epacadostat + FPV-Brachyury + M7824 + MVA-BN-Brachyury FPV-Brachyury + M7824 + MVA-BN-Brachyury ALT-803 + FPV-Brachyury + M7824 + MVA-BN-Brachyury ALT-803 + M7824 Phase I/II Study of Immunotherapy Combination BN-Brachyury Vaccine, M7824, ALT-803 and Epacadostat (QuEST1). Recruiting


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