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Drug Name Entinostat
Trade Name
Synonyms HDAC inhibitor SNDX-275|MS 275
Drug Descriptions

Entinostat (MS-275) inhibits HDAC activity, with selectivity towards HDAC1, 2, and 3, which results in increased histone acetylation, and potentially leads to decreased tumor cell proliferation and tumor growth (PMID: 19724929, PMID: 17383217, PMID: 32503469).

DrugClasses HDAC Inhibitor 45
CAS Registry Number 209783-80-2
NCIT ID C1863

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Ado-trastuzumab emtansine + Bintrafusp alfa + Entinostat + FPV-Brachyury + MVA-BN-Brachyury Ado-trastuzumab emtansine Bintrafusp alfa Entinostat FPV-Brachyury MVA-BN-Brachyury 0 1
Atezolizumab + Bevacizumab + Entinostat Atezolizumab Bevacizumab Entinostat 0 1
Atezolizumab + Carboplatin + Entinostat + Etoposide Atezolizumab Carboplatin Entinostat Etoposide 0 1
Atezolizumab + Entinostat Atezolizumab Entinostat 0 3
Avelumab + Entinostat Avelumab Entinostat 0 1
Azacitidine + Entinostat Azacitidine Entinostat 0 2
Bintrafusp alfa + Entinostat + NHS-IL12 Bintrafusp alfa Entinostat NHS-IL12 0 1
Capecitabine + Entinostat Capecitabine Entinostat 0 1
Cisplatin + Entinostat Cisplatin Entinostat 0 0
Entinostat Entinostat 3 7
Entinostat + Enzalutamide Entinostat Enzalutamide 0 1
Entinostat + Exemestane Entinostat Exemestane 0 1
Entinostat + Exemestane + Goserelin Entinostat Exemestane Goserelin 0 1
Entinostat + H1299 cell lysate vaccine + Montanide ISA 51 + Nivolumab Entinostat H1299 cell lysate vaccine Montanide ISA 51 Nivolumab 0 1
Entinostat + Hydroxychloroquine + Regorafenib Entinostat Hydroxychloroquine Regorafenib 0 1
Entinostat + Interleukin-12 Entinostat Interleukin-12 0 1
Entinostat + Ipilimumab + Nivolumab Entinostat Ipilimumab Nivolumab 0 2
Entinostat + Lapatinib Entinostat Lapatinib 0 0
Entinostat + Lapatinib + Trastuzumab Entinostat Lapatinib Trastuzumab 0 1
Entinostat + Medroxyprogesterone Entinostat Medroxyprogesterone 0 1
Entinostat + NHS-IL12 Entinostat NHS-IL12 0 1
Entinostat + Nivolumab Entinostat Nivolumab 0 2
Entinostat + Olaparib Entinostat Olaparib 0 1
Entinostat + Oxaliplatin Entinostat Oxaliplatin 0 0
Entinostat + Pembrolizumab Entinostat Pembrolizumab 0 6
Entinostat + Temozolomide Entinostat Temozolomide 0 0
Entinostat + Trametinib Entinostat Trametinib 1 0
Entinostat + ZEN-3694 Entinostat ZEN-3694 0 1


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