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Drug Name Entinostat
Trade Name
Synonyms HDAC inhibitor SNDX-275|MS 275
Drug Descriptions

Entinostat (MS-275) inhibits HDAC activity, with selectivity towards HDAC1, 2, and 3, which results in increased histone acetylation, and potentially leads to decreased tumor cell proliferation and tumor growth (PMID: 19724929, PMID: 17383217).

DrugClasses HDAC Inhibitor 37

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Ado-trastuzumab emtansine + Entinostat + FPV-Brachyury + M7824 + MVA-BN-Brachyury Ado-trastuzumab emtansine Entinostat FPV-Brachyury M7824 MVA-BN-Brachyury 0 1
Atezolizumab + Bevacizumab + Entinostat Atezolizumab Bevacizumab Entinostat 0 1
Atezolizumab + Entinostat Atezolizumab Entinostat 0 2
Avelumab + Entinostat Avelumab Entinostat 0 1
Azacitidine + Entinostat Azacitidine Entinostat 1 2
Capecitabine + Entinostat Capecitabine Entinostat 0 1
Entinostat Entinostat 5 7
Entinostat + Enzalutamide Entinostat Enzalutamide 0 1
Entinostat + Exemestane Entinostat Exemestane 0 1
Entinostat + Exemestane + Goserelin Entinostat Exemestane Goserelin 0 1
Entinostat + Hydroxychloroquine + Regorafenib Entinostat Hydroxychloroquine Regorafenib 0 1
Entinostat + Interleukin-12 Entinostat Interleukin-12 0 1
Entinostat + Ipilimumab + Nivolumab Entinostat Ipilimumab Nivolumab 0 2
Entinostat + Lapatinib Entinostat Lapatinib 1 0
Entinostat + Lapatinib + Trastuzumab Entinostat Lapatinib Trastuzumab 1 1
Entinostat + Medroxyprogesterone Entinostat Medroxyprogesterone 0 1
Entinostat + Nivolumab Entinostat Nivolumab 0 1
Entinostat + Olaparib Entinostat Olaparib 0 1
Entinostat + Pembrolizumab Entinostat Pembrolizumab 0 6
Entinostat + Temozolomide Entinostat Temozolomide 0 0


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