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Drug Name Ado-trastuzumab emtansine
Trade Name Kadcyla
Synonyms T-DM1|trastuzumab emtansine
Drug Descriptions

Kadcyla (ado-trastuzumab emtansine) is an antibody drug conjugate combined of the ERBB2 (HER2) monoclonal antibody, trastuzumab, and an anti-tubulin agent, DM1, which results in tumor cell cytotoxicity (PMID: 24887180). Kadcyla (ado-trastuzumab emtansine) is FDA approved for metastatic ERBB2 (HER2)-positive (overexpression or gene amplification) breast cancer patients who have previously received trastuzumab and/or taxane, and for the adjuvant treatment of patients with ERBB2 (HER2)-positive early breast cancer who have residual invasive disease after taxane and trastuzumab-based treatment (FDA.gov).

DrugClasses HER2 (ERBB2) Antibody 36

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Ado-trastuzumab emtansine Abemaciclib Ado-trastuzumab emtansine 0 1
Ado-trastuzumab emtansine Ado-trastuzumab emtansine 32 23
Ado-trastuzumab emtansine + Alpelisib Ado-trastuzumab emtansine Alpelisib 0 1
Ado-trastuzumab emtansine + Capecitabine Ado-trastuzumab emtansine Capecitabine 0 2
Ado-trastuzumab emtansine + Docetaxel Ado-trastuzumab emtansine Docetaxel 1 1
Ado-trastuzumab emtansine + Docetaxel + Pertuzumab Ado-trastuzumab emtansine Docetaxel Pertuzumab 1 0
Ado-trastuzumab emtansine + Entinostat + FPV-Brachyury + M7824 + MVA-BN-Brachyury Ado-trastuzumab emtansine Entinostat FPV-Brachyury M7824 MVA-BN-Brachyury 0 1
Ado-trastuzumab emtansine + FPV-Brachyury + M7824 + MVA-BN-Brachyury Ado-trastuzumab emtansine FPV-Brachyury M7824 MVA-BN-Brachyury 0 1
Ado-trastuzumab emtansine + Lapatinib Ado-trastuzumab emtansine Lapatinib 0 1
Ado-trastuzumab emtansine + Lapatinib + Nab-paclitaxel Ado-trastuzumab emtansine Lapatinib Nab-paclitaxel 0 1
Ado-trastuzumab emtansine + Letrozole + Palbociclib Ado-trastuzumab emtansine Letrozole Palbociclib 0 1
Ado-trastuzumab emtansine + Neratinib Ado-trastuzumab emtansine Neratinib 0 1
Ado-trastuzumab emtansine + Paclitaxel Ado-trastuzumab emtansine Paclitaxel 0 1
Ado-trastuzumab emtansine + Palbociclib Ado-trastuzumab emtansine Palbociclib 0 2
Ado-trastuzumab emtansine + Pembrolizumab Ado-trastuzumab emtansine Pembrolizumab 0 2
Ado-trastuzumab emtansine + Pertuzumab Ado-trastuzumab emtansine Pertuzumab 0 5
Ado-trastuzumab emtansine + Poziotinib Ado-trastuzumab emtansine Poziotinib 4 1
Ado-trastuzumab emtansine + Sargramostim Ado-trastuzumab emtansine Sargramostim 0 1
Ado-trastuzumab emtansine + Sargramostim + TPIV100 Ado-trastuzumab emtansine Sargramostim TPIV100 0 1
Ado-trastuzumab emtansine + Temozolomide Ado-trastuzumab emtansine Temozolomide 0 1
Ado-trastuzumab emtansine + Trastuzumab Ado-trastuzumab emtansine Trastuzumab 0 1
Ado-trastuzumab emtansine + Tucatinib Ado-trastuzumab emtansine Tucatinib 4 2
Ado-trastuzumab emtansine + Utomilumab Ado-trastuzumab emtansine Utomilumab 0 1
Ado-trastuzumab emtansine + Venetoclax Ado-trastuzumab emtansine Venetoclax 0 1
Ado-trastuzumab emtansine + Vinorelbine Ado-trastuzumab emtansine Vinorelbine 0 1


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