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Drug Name DZD1516
Trade Name
Synonyms DZD-1516|DZD 1516
Drug Descriptions

DZD1516 is an ERBB2 (HER2) inhibitor that penetrates the blood brain barrier, and upon binding to ERRB2 (HER2), prevents ERBB2 (HER2)-dependent signaling, potentially leading to tumor cell death (NCI Drug Dictionary).

DrugClasses HER2 Inhibitor 29
CAS Registry Number NA
NCIT ID C174039

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Ado-trastuzumab emtansine + DZD1516 Ado-trastuzumab emtansine DZD1516 0 1
Capecitabine + DZD1516 Capecitabine DZD1516 0 1
Capecitabine + DZD1516 + Trastuzumab Capecitabine DZD1516 Trastuzumab 0 1
DZD1516 DZD1516 0 1
DZD1516 + Trastuzumab DZD1516 Trastuzumab 0 1


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