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Drug Name Mobocertinib
Trade Name Exkivity
Synonyms TAK-788|TAK788|AP32788|AP-32788|AP 32788
Drug Descriptions

Exkivity (mobocertinib) inhibits EGFR and ERBB2 (HER2), with selectivity for mutant forms including EGFR exon 20 insertions, potentially resulting in growth inhibition in EGFR or ERBB2-mutant cancer cells (PMID: 33632775). Exkivity (mobocertinib) is FDA approved for use in patients with locally advanced or metastatic non-small cell lung cancer harboring EGFR exon 20 insertion mutations after disease progression on platinum-based chemotherapy (FDA.gov).

DrugClasses EGFR Inhibitor (Pan) 55 HER2 Inhibitor 35
CAS Registry Number 1847461-43-1
NCIT ID C126752

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Ado-trastuzumab emtansine + Mobocertinib Ado-trastuzumab emtansine Mobocertinib 0 0
Alisertib + Mobocertinib Alisertib Mobocertinib 0 0
Cetuximab + Mobocertinib Cetuximab Mobocertinib 0 0
Mobocertinib Mobocertinib 0 2
Mobocertinib + Sapanisertib Mobocertinib Sapanisertib 0 0


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