Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Mobocertinib
Trade Name Exkivity
Synonyms TAK-788|TAK788|AP32788|AP-32788|AP 32788
Drug Descriptions

Exkivity (mobocertinib) inhibits EGFR and ERBB2 (HER2), with selectivity for mutant forms including EGFR exon 20 insertions, potentially resulting in growth inhibition in EGFR or ERBB2-mutant cancer cells (PMID: 33632775). Exkivity (mobocertinib) is FDA approved for use in patients with locally advanced or metastatic non-small cell lung cancer harboring EGFR exon 20 insertion mutations after disease progression on platinum-based chemotherapy (FDA.gov).

DrugClasses EGFR Inhibitor (Pan) 61 HER2 Inhibitor 41
CAS Registry Number 1847461-43-1
NCIT ID C126752


  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")


  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Ado-trastuzumab emtansine + Mobocertinib Ado-trastuzumab emtansine Mobocertinib 0 0
Alisertib + Mobocertinib Alisertib Mobocertinib 0 0
Bevacizumab + Mobocertinib Bevacizumab Mobocertinib 0 0
Cetuximab + Mobocertinib Cetuximab Mobocertinib 0 0
Mobocertinib Mobocertinib 0 2
Mobocertinib + Sapanisertib Mobocertinib Sapanisertib 0 0
Mobocertinib + Trametinib Mobocertinib Trametinib 0 0

Additional content available in CKB BOOST