Therapy Detail

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Therapy Name Mobocertinib
Synonyms TAK-788|TAK788|AP32788|AP-32788|AP 32788
Therapy Description

Mobocertinib (TAK-788) inhibits EGFR and ERBB2 (HER2), with selectivity for mutant forms including EGFR exon 20 insertions, potentially resulting in growth inhibition in EGFR or ERBB2-mutant cancer cells (AACR, Cancer Res: April 2016; Volume 57, Abstract #2644).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Mobocertinib TAK-788|TAK788|AP32788|AP-32788|AP 32788 EGFR Inhibitor (Pan) 47 HER2 Inhibitor 26 Mobocertinib (TAK-788) inhibits EGFR and ERBB2 (HER2), with selectivity for mutant forms including EGFR exon 20 insertions, potentially resulting in growth inhibition in EGFR or ERBB2-mutant cancer cells (AACR, Cancer Res: April 2016; Volume 57, Abstract #2644, PMID: 32485428).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB2 exon 20 ins Advanced Solid Tumor sensitive Mobocertinib Preclinical - Pdx & cell culture Actionable In a preclinical study, Mobocertinib (TAK-788) inhibited growth of transformed cell lines over expressing ERBB2 (HER2) exon 20 insertions in culture, and induced tumor regression in PDX models (AACR, Cancer Res: April 2016; Volume 57, Abstract #2644). detail...
ERBB2 G776V Advanced Solid Tumor sensitive Mobocertinib Preclinical - Cell culture Actionable In a preclinical study, Mobocertinib (TAK-788) inhibited growth of transformed cell lines over expressing ERBB2 (HER2) G776V in culture (AACR, Cancer Res: April 2016; Volume 57, Abstract #2644). detail...

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04129502 Phase III Mobocertinib Cisplatin + Pemetrexed Disodium Carboplatin + Pemetrexed Disodium TAK-788 as First-line Treatment Versus Platinum-Based Chemotherapy for Non-Small Cell Lung Cancer (NSCLC) With EGFR Exon 20 Insertion Mutations Recruiting USA | CAN 23
NCT02716116 Phase Ib/II Mobocertinib A Trial of TAK-788 (AP32788) in Non-small Cell Lung Cancer (NSCLC) Recruiting USA 8


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