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Drug Name | GDC-0980 |
Trade Name | |
Synonyms | Apitolisib |
Drug Descriptions |
Apitolisib (GDC-0980) is an inhibitor of both PI3K and mTOR kinases, resulting in decreased phosphorylation of PI3K/Akt/mTOR pathway markers, which may lead to inhibition of tumor growth and tumor regression (PMID: 21998291, PMID: 30914027). |
DrugClasses | mTOR Inhibitor 51 PI3K Inhibitor (Pan) 40 |
CAS Registry Number | 1032754-93-0 |
NCIT ID | C91731 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Ado-trastuzumab emtansine + GDC-0980 | Ado-trastuzumab emtansine GDC-0980 | 0 | 0 |
GDC-0980 | GDC-0980 | 10 | 3 |
GDC-0980 + Palbociclib | GDC-0980 Palbociclib | 0 | 0 |
GDC-0980 + PD-0325901 | GDC-0980 PD-0325901 | 0 | 0 |
GDC-0980 + Trastuzumab | GDC-0980 Trastuzumab | 0 | 0 |