Drug Detail


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Drug Name GDC-0980
Trade Name
Synonyms Apitolisib
Drug Descriptions

Apitolisib (GDC-0980) is an inhibitor of both PI3K and mTOR kinases, resulting in decreased phosphorylation of PI3K/Akt/mTOR pathway markers, which may lead to inhibition of tumor growth and tumor regression (PMID: 21998291, PMID: 30914027).

DrugClasses mTOR Inhibitor 51 PI3K Inhibitor (Pan) 40
CAS Registry Number 1032754-93-0
NCIT ID C91731


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Ado-trastuzumab emtansine + GDC-0980 Ado-trastuzumab emtansine GDC-0980 0 0
GDC-0980 GDC-0980 10 3
GDC-0980 + Palbociclib GDC-0980 Palbociclib 0 0
GDC-0980 + PD-0325901 GDC-0980 PD-0325901 0 0
GDC-0980 + Trastuzumab GDC-0980 Trastuzumab 0 0

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