Drug Detail


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Drug Name Apitolisib
Trade Name
Synonyms GDC-0980
Drug Descriptions

Apitolisib (GDC-0980) is an inhibitor of both PI3K and mTOR kinases, resulting in decreased phosphorylation of PI3K/Akt/mTOR pathway markers, which may lead to inhibition of tumor growth and tumor regression (PMID: 21998291, PMID: 30914027).

DrugClasses mTOR Inhibitor 51 PI3K Inhibitor (Pan) 40
CAS Registry Number 1032754-93-0
NCIT ID C91731


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Ado-trastuzumab emtansine + Apitolisib Ado-trastuzumab emtansine Apitolisib 0 0
Apitolisib Apitolisib 10 3
Apitolisib + Palbociclib Apitolisib Palbociclib 0 0
Apitolisib + PD-0325901 Apitolisib PD-0325901 0 0
Apitolisib + Trastuzumab Apitolisib Trastuzumab 0 0

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