Drug Detail


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Drug Name Poziotinib
Trade Name
Synonyms HM781-36B|NOV120101
Drug Descriptions

Poziotinib (HM781-36B) is a pan-ErbB inhibitor that inhibits EGFR, ERBB2 (HER2) and ERBB4 (HER4), thereby reducing proliferation of tumor cells that overexpress these receptors (PMID: 21306821, PMID: 31588020).

DrugClasses EGFR Inhibitor (Pan) 61 HER inhibitor (Pan) 6
CAS Registry Number 1092364-38-9
NCIT ID C98838


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Ado-trastuzumab emtansine + Poziotinib Ado-trastuzumab emtansine Poziotinib 0 1
Capmatinib + Poziotinib Capmatinib Poziotinib 0 0
Fulvestrant + Poziotinib Fulvestrant Poziotinib 0 0
Poziotinib Poziotinib 0 7
Poziotinib + Tepotinib Poziotinib Tepotinib 0 0
Poziotinib + TNO155 Poziotinib TNO155 0 0

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