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TNO155 is an inhibitor of PTPN11 (SHP2), which potentially blocks SHP2 signaling, thereby inhibiting activation of the MAPK pathway and subsequent cell growth (NCI Drug Dictionary).
|DrugClasses||SHP2 Inhibitor 11|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|MRTX849 + TNO155||MRTX849 TNO155||0||1|
|Ribociclib + TNO155||Ribociclib TNO155||0||1|
|Spartalizumab + TNO155||Spartalizumab TNO155||0||1|