Drug Detail


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Drug Name TNO155
Trade Name
Synonyms TNO-155|TNO 155
Drug Descriptions

TNO155 is an inhibitor of PTPN11 (SHP2), which potentially blocks SHP2 signaling, thereby inhibiting activation of the MAPK pathway and subsequent cell growth (NCI Drug Dictionary).

DrugClasses SHP2 Inhibitor 19
CAS Registry Number NA
NCIT ID C139559


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Adagrasib + TNO155 Adagrasib TNO155 0 1
Dabrafenib + LTT462 + TNO155 Dabrafenib LTT462 TNO155 0 1
Dabrafenib + TNO155 + Trametinib Dabrafenib TNO155 Trametinib 0 1
JDQ443 + Spartalizumab + TNO155 JDQ443 Spartalizumab TNO155 0 0
JDQ443 + Tislelizumab + TNO155 JDQ443 TNO155 Tislelizumab 0 1
JDQ443 + TNO155 JDQ443 TNO155 0 1
Ribociclib + TNO155 Ribociclib TNO155 0 1
Sotorasib + TNO155 Sotorasib TNO155 0 1
Spartalizumab + TNO155 Spartalizumab TNO155 0 1
TNO155 TNO155 2 1

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