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Drug Name TNO155
Trade Name
Synonyms
Drug Descriptions

TNO155 is an inhibitor of PTPN11 (SHP2), which potentially blocks SHP2 signaling, thereby inhibiting activation of the MAPK pathway and subsequent cell growth (NCI Drug Dictionary).

DrugClasses SHP2 Inhibitor 11

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Therapy Name Drugs Efficacy Evidence Clinical Trials
MRTX849 + TNO155 MRTX849 TNO155 0 1
Ribociclib + TNO155 Ribociclib TNO155 0 1
Spartalizumab + TNO155 Spartalizumab TNO155 0 1
TNO155 TNO155 0 1


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