Drug Detail


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Drug Name TNO155
Trade Name
Synonyms TNO-155|TNO 155
Drug Descriptions

TNO155 is an inhibitor of PTPN11 (SHP2), which potentially blocks SHP2 signaling, thereby inhibiting activation of the MAPK pathway and subsequent tumor cell growth (PMID: 38032104, Cancer Res (2022) 82 (12_Supplement): 1054).

DrugClasses SHP2 Inhibitor 20
CAS Registry Number NA
NCIT ID C139559


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Adagrasib + TNO155 Adagrasib TNO155 0 1
BI-3406 + TNO155 BI-3406 TNO155 0 0
Ceritinib + TNO155 Ceritinib TNO155 2 0
Crizotinib + TNO155 Crizotinib TNO155 2 0
Dabrafenib + LTT462 + TNO155 Dabrafenib LTT462 TNO155 0 1
Dabrafenib + TNO155 + Trametinib Dabrafenib TNO155 Trametinib 0 1
Entrectinib + TNO155 Entrectinib TNO155 0 0
JDQ443 + Spartalizumab + TNO155 JDQ443 Spartalizumab TNO155 0 0
JDQ443 + Tislelizumab + TNO155 JDQ443 TNO155 Tislelizumab 0 1
JDQ443 + TNO155 JDQ443 TNO155 0 1
Lorlatinib + TNO155 Lorlatinib TNO155 2 0
MRTX1257 + TNO155 MRTX1257 TNO155 0 0
Osimertinib + TNO155 Osimertinib TNO155 0 0
Poziotinib + TNO155 Poziotinib TNO155 0 0
Ribociclib + TNO155 Ribociclib TNO155 0 1
Sotorasib + TNO155 Sotorasib TNO155 0 1
Spartalizumab + TNO155 Spartalizumab TNO155 0 1
TNO155 TNO155 4 1

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