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|Therapy Name||Ribociclib + TNO155|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Ribociclib||Kisqali||LEE011||CDK4/6 Inhibitor 13||Kisqali (ribociclib) is a dual CDK4/6 inhibitor, which may induce cell cycle arrest and reduce proliferation in cancer cells (PMID: 24045179). Kisqali (ribociclib) is FDA-approved in combination with an aromatase inhibitor in women with hormone receptor-positive, ERBB2 (HER2)-negative breast cancer, and in combination with Faslodex (fulvestrant) in postmenopausal women with hormone receptor-positive, ERBB2 (HER2)-negative breast cancer (FDA.gov).|
|TNO155||TNO-155|TNO 155||SHP2 Inhibitor 19||TNO155 is an inhibitor of PTPN11 (SHP2), which potentially blocks SHP2 signaling, thereby inhibiting activation of the MAPK pathway and subsequent cell growth (NCI Drug Dictionary).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT04000529||Phase I||Spartalizumab + TNO155 Ribociclib + TNO155||Phase Ib Study of TNO155 in Combination With Spartalizumab or Ribociclib in Selected Malignancies||Active, not recruiting||USA | ESP | DEU | BEL||5|