Drug Detail


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Drug Name Ceritinib
Trade Name Zykadia
Synonyms LDK378
Drug Descriptions

Zykadia (ceritinib) inhibits ALK, including ALK mutations and fusions, and has additional activity against ROS1 fusions, potentially resulting in decreased tumor cell growth (PMID: 25322323, PMID: 26372962). Zykadia (ceritinib) is FDA approved for ALK-positive (rearrangements and fusions) metastatic non-small cell lung cancer (FDA.gov).

DrugClasses ALK Inhibitor 31 ROS1 Inhibitor 20
CAS Registry Number 1032900-25-6
NCIT ID C115112


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Therapy Name Drugs Efficacy Evidence Clinical Trials
4SC-205 + Ceritinib 4SC-205 Ceritinib 1 0
AXL1717 + Ceritinib AXL1717 Ceritinib 0 0
Bemcentinib + Ceritinib Bemcentinib Ceritinib 0 0
Brentuximab vedotin + Ceritinib Brentuximab vedotin Ceritinib 0 1
Capmatinib + Ceritinib Capmatinib Ceritinib 0 0
Carboplatin + Ceritinib Carboplatin Ceritinib 0 1
Ceritinib Ceritinib 147 20
Ceritinib + CGM097 CGM097 Ceritinib 3 0
Ceritinib + Cisplatin Ceritinib Cisplatin 0 1
Ceritinib + Cisplatin + Gemcitabine Ceritinib Cisplatin Gemcitabine 0 1
Ceritinib + Crizotinib Ceritinib Crizotinib 1 0
Ceritinib + Docetaxel Ceritinib Docetaxel 0 1
Ceritinib + Everolimus Ceritinib Everolimus 0 1
Ceritinib + Fulvestrant Ceritinib Fulvestrant 1 0
Ceritinib + Gemcitabine Ceritinib Gemcitabine 0 1
Ceritinib + Gemcitabine + Nab-paclitaxel Ceritinib Gemcitabine Nab-paclitaxel 0 1
Ceritinib + HJC0152 Ceritinib HJC0152 1 0
Ceritinib + Naxitamab Ceritinib Naxitamab 0 1
Ceritinib + Nivolumab Ceritinib Nivolumab 0 1
Ceritinib + Ribociclib Ceritinib Ribociclib 5 2
Ceritinib + Saracatinib Ceritinib Saracatinib 0 0
Ceritinib + Selumetinib Ceritinib Selumetinib 1 0
Ceritinib + Trametinib Ceritinib Trametinib 0 1

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