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Drug Name Ceritinib
Trade Name Zykadia
Synonyms LDK378
Drug Descriptions

Zykadia (ceritinib) inhibits ALK, including ALK mutations and fusions, and has additional activity against ROS1 fusions, potentially resulting in decreased tumor cell growth (PMID: 25322323, PMID: 26372962). Zykadia (ceritinib) is FDA approved for ALK-positive (rearrangements and fusions) metastatic non-small cell lung cancer (FDA.gov).

DrugClasses ALK Inhibitor 23 ROS1 Inhibitor 14

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bemcentinib + Ceritinib Bemcentinib Ceritinib 0 0
Brentuximab vedotin + Ceritinib Brentuximab vedotin Ceritinib 0 1
Capmatinib + Ceritinib Capmatinib Ceritinib 0 0
Carboplatin + Ceritinib Carboplatin Ceritinib 0 1
Ceritinib Ceritinib 114 19
Ceritinib + CGM097 CGM097 Ceritinib 0 0
Ceritinib + Cisplatin Ceritinib Cisplatin 0 1
Ceritinib + Cisplatin + Gemcitabine Ceritinib Cisplatin Gemcitabine 0 1
Ceritinib + Crizotinib Ceritinib Crizotinib 1 0
Ceritinib + Docetaxel Ceritinib Docetaxel 0 1
Ceritinib + Everolimus Ceritinib Everolimus 0 1
Ceritinib + Fulvestrant Ceritinib Fulvestrant 1 0
Ceritinib + Gemcitabine Ceritinib Gemcitabine 0 1
Ceritinib + Gemcitabine + Nab-paclitaxel Ceritinib Gemcitabine Nab-paclitaxel 0 1
Ceritinib + Nivolumab Ceritinib Nivolumab 0 1
Ceritinib + Ribociclib Ceritinib Ribociclib 0 2
Ceritinib + Saracatinib Ceritinib Saracatinib 1 0
Ceritinib + Selumetinib Ceritinib Selumetinib 1 0
Ceritinib + Trametinib Ceritinib Trametinib 0 1


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