Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Cobimetinib
Trade Name Cotellic
Synonyms GDC-0973
Drug Descriptions

Cotellic (cobimetinib) is an allosteric inhibitor of MEK1/2, resulting in inhibition of extracellular signal-related kinase 2 (ERK2) phosphorylation and activation and decreased tumor cell proliferation (PMID: 22084396, PMID: 27956260). Cotellic (cobimetinib) is FDA approved for use in combination with Zelboraf (vemurafenib) in melanoma patients harboring BRAF V600E or V600K (FDA.gov).

DrugClasses MEK inhibitor (Pan) 24 MEK1 Inhibitor 26 MEK2 Inhibitor 24
CAS Registry Number 934660-93-2
NCIT ID C68923

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
A-1210477 + Cobimetinib A-1210477 Cobimetinib 0 0
A-1210477 + Cobimetinib + Vemurafenib A-1210477 Cobimetinib Vemurafenib 0 0
ABM-1310 + Cobimetinib ABM-1310 Cobimetinib 1 1
Alectinib + Cobimetinib Alectinib Cobimetinib 0 1
APG-1252 + Cobimetinib APG-1252 Cobimetinib 0 1
Atezolizumab + Belvarafenib + Cobimetinib Atezolizumab Belvarafenib Cobimetinib 0 0
Atezolizumab + Bevacizumab + Cobimetinib Atezolizumab Bevacizumab Cobimetinib 0 3
Atezolizumab + Cobimetinib Atezolizumab Cobimetinib 0 18
Atezolizumab + Cobimetinib + Eribulin Atezolizumab Cobimetinib Eribulin 0 1
Atezolizumab + Cobimetinib + Fluorouracil + Leucovorin + Oxaliplatin Atezolizumab Cobimetinib Fluorouracil Leucovorin Oxaliplatin 0 1
Atezolizumab + Cobimetinib + Hydroxychloroquine Atezolizumab Cobimetinib Hydroxychloroquine 0 1
Atezolizumab + Cobimetinib + Nab-paclitaxel Atezolizumab Cobimetinib Nab-paclitaxel 0 1
Atezolizumab + Cobimetinib + Niraparib Atezolizumab Cobimetinib Niraparib 0 1
Atezolizumab + Cobimetinib + Paclitaxel Atezolizumab Cobimetinib Paclitaxel 0 1
Atezolizumab + Cobimetinib + Varlilumab Atezolizumab Cobimetinib Varlilumab 0 1
Atezolizumab + Cobimetinib + Vemurafenib Atezolizumab Cobimetinib Vemurafenib 5 7
Belvarafenib + Cobimetinib Belvarafenib Cobimetinib 5 1
Belvarafenib + Cobimetinib + Nivolumab Belvarafenib Cobimetinib Nivolumab 0 1
BI 853520 + Cobimetinib BI 853520 Cobimetinib 0 1
Calaspargase pegol-mknl + Cobimetinib Calaspargase pegol-mknl Cobimetinib 0 1
Cobimetinib Cobimetinib 87 10
Cobimetinib + Dexamethasone + Ixazomib + Pomalidomide Cobimetinib Dexamethasone Ixazomib Pomalidomide 0 1
Cobimetinib + Duligotuzumab Cobimetinib Duligotuzumab 0 1
Cobimetinib + Enasidenib Cobimetinib Enasidenib 0 1
Cobimetinib + Gemcitabine + Nab-paclitaxel Cobimetinib Gemcitabine Nab-paclitaxel 1 0
Cobimetinib + Ipatasertib Cobimetinib Ipatasertib 0 1
Cobimetinib + Ipilimumab + Nivolumab Cobimetinib Ipilimumab Nivolumab 0 1
Cobimetinib + LY3022855 + Vemurafenib Cobimetinib LY3022855 Vemurafenib 0 1
Cobimetinib + Nab-paclitaxel Cobimetinib Nab-paclitaxel 0 0
Cobimetinib + Niraparib Cobimetinib Niraparib 0 1
Cobimetinib + Onartuzumab Cobimetinib Onartuzumab 0 1
Cobimetinib + Onartuzumab + Vemurafenib Cobimetinib Onartuzumab Vemurafenib 0 1
Cobimetinib + Paclitaxel Cobimetinib Paclitaxel 0 1
Cobimetinib + Pembrolizumab + Vemurafenib Cobimetinib Pembrolizumab Vemurafenib 2 1
Cobimetinib + Pictilisib Cobimetinib Pictilisib 0 1
Cobimetinib + Ravoxertinib Cobimetinib Ravoxertinib 0 0
Cobimetinib + RMC-4630 Cobimetinib RMC-4630 0 1
Cobimetinib + Selumetinib Cobimetinib Selumetinib 0 0
Cobimetinib + UNC2025 Cobimetinib UNC2025 1 0
Cobimetinib + Vemurafenib Cobimetinib Vemurafenib 49 14
Cobimetinib + Vemurafenib + XL888 Cobimetinib Vemurafenib XL888 0 1
Cobimetinib + Venetoclax Cobimetinib Venetoclax 0 1
Cobimetinib + VS-4718 Cobimetinib VS-4718 0 0


Additional content available in CKB BOOST