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Drug Name Cobimetinib
Trade Name Cotellic
Synonyms GDC-0973
Drug Descriptions

Cotellic (cobimetinib) is an allosteric inhibitor of MEK1/2, resulting in inhibition of extracellular signal-related kinase 2 (ERK2) phosphorylation and activation and decreased tumor cell proliferation (PMID: 22084396, PMID: 27956260). Cotellic (cobimetinib) is FDA approved for use in combination with Zelboraf (vemurafenib) in melanoma patients harboring BRAF V600E or V600K (FDA.gov).

DrugClasses MEK inhibitor (Pan) 22 MEK1 Inhibitor 20 MEK2 Inhibitor 18
CAS Registry Number 934660-93-2
NCIT ID C68923

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Therapy Name Drugs Efficacy Evidence Clinical Trials
A-1210477 + Cobimetinib A-1210477 Cobimetinib 0 0
A-1210477 + Cobimetinib + Vemurafenib A-1210477 Cobimetinib Vemurafenib 0 0
Alectinib + Cobimetinib Alectinib Cobimetinib 0 1
Atezolizumab + Belvarafenib + Cobimetinib Atezolizumab Belvarafenib Cobimetinib 0 1
Atezolizumab + Bevacizumab + Cobimetinib Atezolizumab Bevacizumab Cobimetinib 0 2
Atezolizumab + Cobimetinib Atezolizumab Cobimetinib 0 17
Atezolizumab + Cobimetinib + Eribulin Atezolizumab Cobimetinib Eribulin 0 1
Atezolizumab + Cobimetinib + Fluorouracil + Leucovorin + Oxaliplatin Atezolizumab Cobimetinib Fluorouracil Leucovorin Oxaliplatin 0 1
Atezolizumab + Cobimetinib + Hydroxychloroquine Atezolizumab Cobimetinib Hydroxychloroquine 0 1
Atezolizumab + Cobimetinib + Nab-paclitaxel Atezolizumab Cobimetinib Nab-paclitaxel 0 1
Atezolizumab + Cobimetinib + Niraparib Atezolizumab Cobimetinib Niraparib 0 1
Atezolizumab + Cobimetinib + Paclitaxel Atezolizumab Cobimetinib Paclitaxel 0 1
Atezolizumab + Cobimetinib + Varlilumab Atezolizumab Cobimetinib Varlilumab 0 1
Atezolizumab + Cobimetinib + Vemurafenib Atezolizumab Cobimetinib Vemurafenib 3 6
Belvarafenib + Cobimetinib Belvarafenib Cobimetinib 3 1
BI 853520 + Cobimetinib BI 853520 Cobimetinib 0 1
Calaspargase pegol-mknl + Cobimetinib Calaspargase pegol-mknl Cobimetinib 0 1
Cobimetinib Cobimetinib 19 8
Cobimetinib + Dexamethasone + Ixazomib + Pomalidomide Cobimetinib Dexamethasone Ixazomib Pomalidomide 0 1
Cobimetinib + Duligotuzumab Cobimetinib Duligotuzumab 0 1
Cobimetinib + Gemcitabine + Nab-paclitaxel Cobimetinib Gemcitabine Nab-paclitaxel 1 0
Cobimetinib + Ipatasertib Cobimetinib Ipatasertib 0 1
Cobimetinib + Ipilimumab + Nivolumab Cobimetinib Ipilimumab Nivolumab 0 1
Cobimetinib + LY3022855 + Vemurafenib Cobimetinib LY3022855 Vemurafenib 0 1
Cobimetinib + Nab-paclitaxel Cobimetinib Nab-paclitaxel 0 0
Cobimetinib + Niraparib Cobimetinib Niraparib 0 1
Cobimetinib + Onartuzumab Cobimetinib Onartuzumab 0 1
Cobimetinib + Onartuzumab + Vemurafenib Cobimetinib Onartuzumab Vemurafenib 0 1
Cobimetinib + Paclitaxel Cobimetinib Paclitaxel 0 1
Cobimetinib + Pembrolizumab + Vemurafenib Cobimetinib Pembrolizumab Vemurafenib 2 1
Cobimetinib + Pictilisib Cobimetinib Pictilisib 0 1
Cobimetinib + Ravoxertinib Cobimetinib Ravoxertinib 0 0
Cobimetinib + RMC-4630 Cobimetinib RMC-4630 0 1
Cobimetinib + Selumetinib Cobimetinib Selumetinib 0 0
Cobimetinib + UNC2025 Cobimetinib UNC2025 1 0
Cobimetinib + Vemurafenib Cobimetinib Vemurafenib 19 11
Cobimetinib + Vemurafenib + XL888 Cobimetinib Vemurafenib XL888 0 1
Cobimetinib + Venetoclax Cobimetinib Venetoclax 0 1
Cobimetinib + VS-4718 Cobimetinib VS-4718 0 0


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