Drug Detail

Drug Name Cobimetinib
Trade Name Cotellic
Synonyms GDC-0973
Drug Descriptions

Cotellic (cobimetinib) is an allosteric inhibitor of MEK1/2, resulting in inhibition of extracellular signal-related kinase 2 (ERK2) phosphorylation and activation and decreased tumor cell proliferation (PMID: 22084396, PMID: 27956260). Cotellic (cobimetinib) is FDA approved for melanoma patients with BRAF V600E or V600K, in combination with Zelboraf (vemurafenib) (FDA.gov).

DrugClasses MEK inhibitor (Pan) 20 MEK1 Inhibitor 20 MEK2 Inhibitor 18

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Therapy Name Drugs Efficacy Evidence Clinical Trials
A-1210477 + Cobimetinib A-1210477 Cobimetinib 0 0
A-1210477 + Cobimetinib + Vemurafenib A-1210477 Cobimetinib Vemurafenib 0 0
Alectinib + Cobimetinib Alectinib Cobimetinib 0 1
Atezolizumab + Bevacizumab + Cobimetinib Atezolizumab Bevacizumab Cobimetinib 0 2
Atezolizumab + Cobimetinib Atezolizumab Cobimetinib 3 15
Atezolizumab + Cobimetinib + Eribulin Atezolizumab Cobimetinib Eribulin 0 1
Atezolizumab + Cobimetinib + Fluorouracil + Leucovorin + Oxaliplatin Atezolizumab Cobimetinib Fluorouracil Leucovorin Oxaliplatin 0 1
Atezolizumab + Cobimetinib + Niraparib Atezolizumab Cobimetinib Niraparib 0 1
Atezolizumab + Cobimetinib + Vemurafenib Atezolizumab Cobimetinib Vemurafenib 1 3
Cobimetinib Cobimetinib 22 4
Cobimetinib + Dexamethasone + Ixazomib + Pomalidomide Cobimetinib Dexamethasone Ixazomib Pomalidomide 0 1
Cobimetinib + Duligotuzumab Cobimetinib Duligotuzumab 1 1
Cobimetinib + Ipatasertib Cobimetinib Ipatasertib 2 1
Cobimetinib + Ipilimumab + Nivolumab Cobimetinib Ipilimumab Nivolumab 0 1
Cobimetinib + LY3022855 + Vemurafenib Cobimetinib LY3022855 Vemurafenib 0 1
Cobimetinib + Niraparib Cobimetinib Niraparib 0 1
Cobimetinib + Onartuzumab Cobimetinib Onartuzumab 0 1
Cobimetinib + Onartuzumab + Vemurafenib Cobimetinib Onartuzumab Vemurafenib 0 1
Cobimetinib + Paclitaxel Cobimetinib Paclitaxel 0 0
Cobimetinib + Pictilisib Cobimetinib Pictilisib 0 0
Cobimetinib + RMC-4630 Cobimetinib RMC-4630 0 1
Cobimetinib + Vemurafenib Cobimetinib Vemurafenib 10 9
Cobimetinib + Vemurafenib + XL888 Cobimetinib Vemurafenib XL888 0 1
Cobimetinib + Venetoclax Cobimetinib Venetoclax 0 1