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Drug Name VS-4718
Trade Name
Drug Descriptions

VS-4718 is a focal adhesion kinase (FAK) inhibitor, which prevents FAK autophosphorylation and activation of downstream YAP1 and Hippo pathway signaling, potentially resulting in decreased tumor cell proliferation, migration, and survival (PMID: 30773340).

DrugClasses FAK inhibitor 15
CAS Registry Number 1061353-68-1
NCIT ID C107238


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cobimetinib + VS-4718 Cobimetinib VS-4718 0 0
Gemcitabine + Nab-paclitaxel + VS-4718 Gemcitabine Nab-paclitaxel VS-4718 0 1
RO5126766 + VS-4718 RO5126766 VS-4718 0 0
Selumetinib + VS-4718 Selumetinib VS-4718 0 0
Trametinib + VS-4718 Trametinib VS-4718 0 0
VS-4718 VS-4718 0 1

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