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Drug Name Varlilumab
Trade Name
Synonyms anti-CD27 monoclonal antibody CDX-1127
Drug Descriptions

Varlilumab is an activating monoclonal antibody that binds to CD27 and potentially increases antibody-dependent cellular cytotoxicity towards CD27 positive tumor cells (PMID: 22589397).

DrugClasses

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Therapy Name Drugs Efficacy Evidence Clinical Trials
6MHP vaccine + Montanide ISA 51 + Poly ICLC + Varlilumab 6MHP vaccine Montanide ISA 51 Poly ICLC Varlilumab 0 1
Atezolizumab + Varlilumab Atezolizumab Varlilumab 0 2
Nivolumab + Varlilumab Nivolumab Varlilumab 2 3
pp65 Dendritic Cell Vaccine + Temozolomide + Varlilumab Temozolomide Varlilumab pp65 Dendritic Cell Vaccine 0 1
Sunitinib + Varlilumab Sunitinib Varlilumab 0 1
Varlilumab Varlilumab 0 3


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