Drug Detail


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Drug Name Varlilumab
Trade Name
Synonyms CDX-1127|CDX127
Drug Descriptions

Varlilumab (CDX-1127) is an activating monoclonal antibody that binds to CD27 and potentially increases antibody-dependent cellular cytotoxicity towards CD27 positive tumor cells (PMID: 22589397, PMID: 32380537).

DrugClasses CD27 Antibody 3
CAS Registry Number 1393344-72-3
NCIT ID C99127


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Therapy Name Drugs Efficacy Evidence Clinical Trials
6MHP vaccine + Montanide ISA 51 + Poly ICLC + Varlilumab 6MHP vaccine Montanide ISA 51 Poly ICLC Varlilumab 0 1
Atezolizumab + Cobimetinib + Varlilumab Atezolizumab Cobimetinib Varlilumab 0 1
Atezolizumab + Varlilumab Atezolizumab Varlilumab 0 3
Nivolumab + Varlilumab Nivolumab Varlilumab 0 3
pp65 Dendritic Cell Vaccine + Temozolomide + Varlilumab Temozolomide Varlilumab pp65 Dendritic Cell Vaccine 0 1
Sunitinib + Varlilumab Sunitinib Varlilumab 0 1
Varlilumab Varlilumab 0 3

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