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Therapy Name pp65 Dendritic Cell Vaccine + Temozolomide + Varlilumab
Synonyms
Therapy Description

Pp65 dendritic cell vaccine is a cancer vaccine composed of autologous dendritic cells modified to express pp65, which potentially results in increased immune response against pp65-expressing tumors (PMID: 25762141, PMID: 28411277).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Temozolomide Temodar Methazolastone Chemotherapy - Alkylating 14 Temodar (temozolomide) is a dacarbazine analog and cytotoxic alkylating agent (NCI Drug Dictionary).
Varlilumab anti-CD27 monoclonal antibody CDX-1127 Varlilumab is an activating monoclonal antibody that binds to CD27 and potentially increases antibody-dependent cellular cytotoxicity towards CD27 positive tumor cells (PMID: 22589397).
pp65 Dendritic Cell Vaccine pp65 DC Vaccine Pp65 dendritic cell vaccine is a cancer vaccine composed of autologous dendritic cells modified to express pp65, which potentially results in increased immune response against pp65-expressing tumors (PMID: 25762141, PMID: 28411277).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
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  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status
NCT03688178 Phase II pp65 Dendritic Cell Vaccine + Temozolomide pp65 Dendritic Cell Vaccine + Temozolomide + Varlilumab DC Migration Study to Evaluate TReg Depletion In GBM Patients With and Without Varlilumab (DERIVe) Recruiting


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