Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name APG-1252
Trade Name
Synonyms BM-1252|Pelcitoclax|APG1252|APG 1252
Drug Descriptions

Pelcitoclax (APG-1252) inhibits BCL2 and BCL-XL, which potentially leads to tumor growth inhibition (J Clin Oncol 40, no. 16_suppl (June 01, 2022) 9116).

DrugClasses BCL-XL inhibitor 14 BCL2 inhibitor 27
CAS Registry Number 1619923-36-2
NCIT ID C148488


  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")


  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
APG-1252 APG-1252 0 1
APG-1252 + Cobimetinib APG-1252 Cobimetinib 0 1
APG-1252 + Osimertinib APG-1252 Osimertinib 0 0
APG-1252 + Paclitaxel APG-1252 Paclitaxel 0 1

Additional content available in CKB BOOST