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Drug Name Calaspargase pegol-mknl
Trade Name Asparlas
Synonyms CALASP|EZN-2285EZN 2285|EZN2285|SC-PEG E. coli L-asparaginase
Drug Descriptions

Asparlas (calaspargase pegol-mknl) is a pegylated version of L-asparaginase derived from E.coli, which converts L-asparagine to ammonia and L-aspartic acid, potentially resulting in reduced levels of asparagine leading to inhibition of protein synthesis and tumor cell proliferation, and increased cell death (NCI Drug Dictionary). Asparlas (calaspargase pegol-mknl) is approved as a component of multi-agent chemotherapy in acute lymphoblastic leukemia (FDA.gov).

CAS Registry Number 941577-06-6
NCIT ID C78198


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Calaspargase pegol-mknl Calaspargase pegol-mknl 0 0
Calaspargase pegol-mknl + Cobimetinib Calaspargase pegol-mknl Cobimetinib 0 1
Calaspargase pegol-mknl + Dexamethasone + Etoposide + Ifosfamide + Methotrexate Calaspargase pegol-mknl Dexamethasone Etoposide Ifosfamide Methotrexate 0 1

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