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|Drug Name||Calaspargase pegol-mknl|
|Synonyms||CALASP|EZN-2285EZN 2285|EZN2285|SC-PEG E. coli L-asparaginase|
Asparlas (calaspargase pegol-mknl) is a pegylated version of L-asparaginase derived from E.coli, which converts L-asparagine to ammonia and L-aspartic acid, potentially resulting in reduced levels of asparagine leading to inhibition of protein synthesis and tumor cell proliferation, and increased cell death (NCI Drug Dictionary). Asparlas (calaspargase pegol-mknl) is approved as a component of multi-agent chemotherapy in acute lymphoblastic leukemia (FDA.gov).
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|Calaspargase pegol-mknl||Calaspargase pegol-mknl||0||0|
|Calaspargase pegol-mknl + Dexamethasone + Etoposide + Ifosfamide + Methotrexate||Calaspargase pegol-mknl Dexamethasone Etoposide Ifosfamide Methotrexate||0||1|