Drug Detail

Drug Name Ipatasertib
Trade Name
Synonyms GDC-0068
Drug Descriptions

Ipatasertib (GDC-0068) binds to and inhibits the activity of AKT in an ATP-competitive manner, which may result in the inhibition of the PI3K/AKT signaling pathway and tumor cell proliferation (PMID: 22934575).

DrugClasses Akt Inhibitor (Pan) 17

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Therapy Name Drugs Efficacy Evidence Clinical Trials
A-1331852 + Ipatasertib A-1331852 Ipatasertib 0 0
Abiraterone + Ipatasertib Abiraterone Ipatasertib 1 1
Atezolizumab + Fulvestrant + Ipatasertib Atezolizumab Fulvestrant Ipatasertib 0 1
Atezolizumab + Ipatasertib Atezolizumab Ipatasertib 0 2
Atezolizumab + Ipatasertib + Nab-paclitaxel Atezolizumab Ipatasertib Nab-paclitaxel 0 1
Atezolizumab + Ipatasertib + Paclitaxel Atezolizumab Ipatasertib Paclitaxel 0 1
Carboplatin + Ipatasertib Carboplatin Ipatasertib 0 1
Carboplatin + Ipatasertib + Paclitaxel Carboplatin Ipatasertib Paclitaxel 0 1
Cobimetinib + Ipatasertib Cobimetinib Ipatasertib 1 1
Fulvestrant + Ipatasertib Fulvestrant Ipatasertib 0 1
Fulvestrant + Ipatasertib + Palbociclib Fulvestrant Ipatasertib Palbociclib 0 1
GSK2334470 + Ipatasertib GSK2334470 Ipatasertib 0 0
Ipatasertib Ipatasertib 6 5
Ipatasertib + Navitoclax Ipatasertib Navitoclax 0 0
Ipatasertib + Paclitaxel Ipatasertib Paclitaxel 6 2
Ipatasertib + Rucaparib Ipatasertib Rucaparib 0 1
Ipatasertib + SCH772984 Ipatasertib SCH772984 0 0
Ipatasertib + Selumetinib Ipatasertib Selumetinib 0 0
Ipatasertib + Sirolimus Ipatasertib Sirolimus 0 0
Ipatasertib + Temsirolimus Ipatasertib Temsirolimus 0 0


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