Drug Detail


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Drug Name Darolutamide
Trade Name Nubeqa
Synonyms BAY1841788|ODM-201
Drug Descriptions

Nubeqa (darolutamide) is an androgen receptor antagonist that binds to and prevents nuclear translocation of the androgen receptor, thereby inhibiting expression of genes downstream of androgen receptor signaling that regulate proliferation of prostate cancer cells (PMID: 28490267). Nubeqa (darolutamide) is FDA approved for use in patients with non-metastatic castration-resistant prostate cancer, and in combination with docetaxel in patients with metastatic hormone-sensitive prostate cancer (FDA.gov).

DrugClasses Hormone - Anti-androgens 47
CAS Registry Number 1297538-32-9
NCIT ID C104748


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Darolutamide Abemaciclib Darolutamide 0 1
Abemaciclib + Darolutamide + Degarelix + Goserelin + Leuprolide Abemaciclib Darolutamide Degarelix Goserelin Leuprolide 0 1
Avelumab + Darolutamide Avelumab Darolutamide 0 0
AZD5305 + Darolutamide AZD5305 Darolutamide 0 3
BAY3546828 + Darolutamide BAY3546828 Darolutamide 0 0
Bicalutamide + Darolutamide Bicalutamide Darolutamide 0 0
Buserelin + Darolutamide Buserelin Darolutamide 0 1
Darolutamide Darolutamide 0 25
Darolutamide + Dasatinib Darolutamide Dasatinib 0 1
Darolutamide + Degarelix Darolutamide Degarelix 0 2
Darolutamide + Degarelix + Goserelin + Leuprolide Darolutamide Degarelix Goserelin Leuprolide 0 1
Darolutamide + Docetaxel Darolutamide Docetaxel 0 2
Darolutamide + Goserelin Darolutamide Goserelin 0 2
Darolutamide + Histrelin acetate Darolutamide Histrelin acetate 0 1
Darolutamide + Ipatasertib Darolutamide Ipatasertib 0 1
Darolutamide + Leuprolide Darolutamide Leuprolide 0 3
Darolutamide + PMD-026 Darolutamide PMD-026 0 0
Darolutamide + Radium Ra 223 dichloride Darolutamide Radium Ra 223 dichloride 0 1
Darolutamide + Relugolix Darolutamide Relugolix 0 1
Darolutamide + Triptorelin Darolutamide Triptorelin 0 2

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