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Drug Name lutetium Lu 177 vipivotide tetraxetan
Trade Name Pluvicto
Synonyms Lu177-PSMA-617|Vipivotide tetraxetan Lu-177
Drug Descriptions

Pluvicto (lutetium Lu 177 vipivotide tetraxetan) is a radioconjugate comprising a prostate-specific membrane antigen (PSMA) inhibitor radiolabeled with Lu177, which targets PSMA expressing cells, potentially resulting in decreased tumor growth (PMID: 25883127, PMID: 26795286, PMID: 32760622). Pluvicto (lutetium Lu 177 vipivotide tetraxetan) is FDA approved for use in patients with PSMA-positive metastatic castration-resistant prostate cancer (mCRPC) who have received androgen receptor (AR) pathway inhibition and taxane-based chemotherapy (FDA.gov).

DrugClasses
CAS Registry Number 1703749-62-5
NCIT ID C148145

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Therapy Name Drugs Efficacy Evidence Clinical Trials
177Lu-J591 + lutetium Lu 177 vipivotide tetraxetan 177Lu-J591 lutetium Lu 177 vipivotide tetraxetan 0 1
Abemaciclib + lutetium Lu 177 vipivotide tetraxetan Abemaciclib lutetium Lu 177 vipivotide tetraxetan 0 1
Cabazitaxel + lutetium Lu 177 vipivotide tetraxetan Cabazitaxel lutetium Lu 177 vipivotide tetraxetan 0 1
Docetaxel + lutetium Lu 177 vipivotide tetraxetan Docetaxel lutetium Lu 177 vipivotide tetraxetan 0 1
Enzalutamide + lutetium Lu 177 vipivotide tetraxetan Enzalutamide lutetium Lu 177 vipivotide tetraxetan 0 1
Ipilimumab + lutetium Lu 177 vipivotide tetraxetan + Nivolumab Ipilimumab Nivolumab lutetium Lu 177 vipivotide tetraxetan 0 1
lutetium Lu 177 vipivotide tetraxetan lutetium Lu 177 vipivotide tetraxetan 0 9
lutetium Lu 177 vipivotide tetraxetan + NOX66 NOX66 lutetium Lu 177 vipivotide tetraxetan 0 0
lutetium Lu 177 vipivotide tetraxetan + Olaparib Olaparib lutetium Lu 177 vipivotide tetraxetan 0 1
lutetium Lu 177 vipivotide tetraxetan + Pembrolizumab Pembrolizumab lutetium Lu 177 vipivotide tetraxetan 0 1


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