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Drug Name Giredestrant
Trade Name
Synonyms RG6171|GDC9545|GDC 9545|GDC-9545)
Drug Descriptions

Giredestrant (GDC-9545) is a selective estrogen receptor degrader (SERD) that prevents cell proliferation of ER-positive cells (Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020) 1023-1023).

DrugClasses Hormone - Anti-estrogens 25
CAS Registry Number 1953133-47-5
NCIT ID C147030

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Giredestrant Abemaciclib Giredestrant 0 4
Everolimus + Giredestrant Everolimus Giredestrant 0 2
Giredestrant Giredestrant 0 9
Giredestrant + Inavolisib Giredestrant Inavolisib 0 2
Giredestrant + Ipatasertib Giredestrant Ipatasertib 0 1
Giredestrant + Palbociclib Giredestrant Palbociclib 0 4
Giredestrant + Pertuzumab/trastuzumab/hyaluronidase-zzxf Giredestrant Pertuzumab/trastuzumab/hyaluronidase-zzxf 0 1
Giredestrant + Ribociclib Giredestrant Ribociclib 0 2
Giredestrant + Triptorelin Giredestrant Triptorelin 0 1


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