Drug Detail


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Drug Name Pertuzumab/trastuzumab/hyaluronidase-zzxf
Trade Name Phesgo
Drug Descriptions

Phesgo (pertuzumab/trastuzumab/hyaluronidase-zzxf) is an injectable formulation consists of Perjeta (pertuzumab), Herceptin (trastuzumab), and hyaluronidase, which demonstrates anti-tumor activity against ERBB2 (HER2)-positive breast cancer (Cancer Res 2020;80(4 Suppl):Abstract nr PD4-07). Phesgo (pertuzumab, trastuzumab, and hyaluronidase-zzxf injection) is FDA approved for use in combination with chemotherapy in ERBB2 (HER2)-positive early breast cancer, and in combination with Taxotere (docetaxel) in ERBB2 (HER2)-positive metastatic breast cancer that has not received prior anti-HER2 therapy (FDA.gov).

DrugClasses HER2 (ERBB2) Antibody 73
CAS Registry Number NA


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + Pertuzumab/trastuzumab/hyaluronidase-zzxf Atezolizumab Pertuzumab/trastuzumab/hyaluronidase-zzxf 0 1
Capecitabine + Pertuzumab/trastuzumab/hyaluronidase-zzxf Capecitabine Pertuzumab/trastuzumab/hyaluronidase-zzxf 0 1
Carboplatin + Paclitaxel + Pertuzumab/trastuzumab/hyaluronidase-zzxf Carboplatin Paclitaxel Pertuzumab/trastuzumab/hyaluronidase-zzxf 0 1
Docetaxel + Paclitaxel + Pertuzumab/trastuzumab/hyaluronidase-zzxf Docetaxel Paclitaxel Pertuzumab/trastuzumab/hyaluronidase-zzxf 0 1
Docetaxel + Pertuzumab/trastuzumab/hyaluronidase-zzxf Docetaxel Pertuzumab/trastuzumab/hyaluronidase-zzxf 0 1
Enzalutamide + Pertuzumab/trastuzumab/hyaluronidase-zzxf Enzalutamide Pertuzumab/trastuzumab/hyaluronidase-zzxf 0 1
Giredestrant + Pertuzumab/trastuzumab/hyaluronidase-zzxf Giredestrant Pertuzumab/trastuzumab/hyaluronidase-zzxf 0 1
Inavolisib + Pertuzumab/trastuzumab/hyaluronidase-zzxf Inavolisib Pertuzumab/trastuzumab/hyaluronidase-zzxf 0 1
Inavolisib + Pertuzumab/trastuzumab/hyaluronidase-zzxf + Tamoxifen Inavolisib Pertuzumab/trastuzumab/hyaluronidase-zzxf Tamoxifen 0 1
Paclitaxel + Pertuzumab/trastuzumab/hyaluronidase-zzxf Paclitaxel Pertuzumab/trastuzumab/hyaluronidase-zzxf 0 1
Pertuzumab/trastuzumab/hyaluronidase-zzxf Pertuzumab/trastuzumab/hyaluronidase-zzxf 0 5
Pertuzumab/trastuzumab/hyaluronidase-zzxf + Tamoxifen Pertuzumab/trastuzumab/hyaluronidase-zzxf Tamoxifen 0 1
Pertuzumab/trastuzumab/hyaluronidase-zzxf + ZN-A-1041 Pertuzumab/trastuzumab/hyaluronidase-zzxf ZN-A-1041 0 1

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