Therapy Detail

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Therapy Name Inavolisib + Pertuzumab/trastuzumab/hyaluronidase-zzxf + Tamoxifen
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Inavolisib GDC-0077|RO7113755|RG6114|GDC0077|GDC 0077 PIK3CA inhibitor 23 Inavolisib (GDC-0077) inhibits PIK3CA, with selectivity for mutant PIK3CA over wild-type PIK3CA, potentially resulting in increased apoptosis and decreased growth of PIK3CA-mutant tumors (PMID: 36455032).
Pertuzumab/trastuzumab/hyaluronidase-zzxf Phesgo HER2 (ERBB2) Antibody 72 Phesgo (pertuzumab/trastuzumab/hyaluronidase-zzxf) is an injectable formulation consists of Perjeta (pertuzumab), Herceptin (trastuzumab), and hyaluronidase, which demonstrates anti-tumor activity against ERBB2 (HER2)-positive breast cancer (Cancer Res 2020;80(4 Suppl):Abstract nr PD4-07). Phesgo (pertuzumab, trastuzumab, and hyaluronidase-zzxf injection) is FDA approved for use in combination with chemotherapy in ERBB2 (HER2)-positive early breast cancer, and in combination with Taxotere (docetaxel) in ERBB2 (HER2)-positive metastatic breast cancer that has not received prior anti-HER2 therapy (FDA.gov).
Tamoxifen Nolvadex ICI-46474 Hormone Antineoplastics 5 Nolvadex (tamoxifen) is a selective estrogen receptor modulator (SERM), which decreases DNA synthesis and cell growth and is FDA approved for breast cancer (FDA.gov).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05306041 Phase II Inavolisib + Pertuzumab/trastuzumab/hyaluronidase-zzxf + Tamoxifen Pertuzumab/trastuzumab/hyaluronidase-zzxf + Tamoxifen Neoadjuvant Endocrine Therapy +/- the PI3K Inhibitor Inavolisib in HER2+, HR+, PIK3CA Mutant Early Breast Cancer (GeparPiPPa) Recruiting DEU 0


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