Therapy Detail

Therapy Name GDC-9545
Synonym
Therapy Description

GDC-9545 is a selective estrogen receptor degrader (SERD) that prevents cell proliferation of ER-positive cells (NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
GDC-9545 RG6171 Hormone - Anti-estrogens 16 GDC-9545 is a selective estrogen receptor degrader (SERD) that prevents cell proliferation of ER-positive cells (NCI Drug Dictionary).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Clinical Trial Phase Therapies Title Recruitment Status
NCT03332797 Phase I GDC-9545 + Palbociclib GDC-9545 A Study of GDC-9545 Alone or in Combination With Palbociclib and/or Luteinizing Hormone-Releasing Hormone (LHRH) Agonist in Locally Advanced or Metastatic Estrogen Receptor-Positive Breast Cancer Recruiting
NCT03916744 Phase I GDC-9545 A Study of GDC-9545 in Postmenopausal Women With Stage I-III Operable, Estrogen Receptor-Positive Breast Cancer Recruiting