Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Niraparib
Trade Name Zejula
Synonyms MK4827
Drug Descriptions

Zejula (niraparib) binds to and inhibits PARP, which may result in the accumulation of DNA damage and apoptosis of tumor cells (PMID: 23810788). Zejula (niraparib) is FDA-approved for use as maintenance therapy in patients with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer in complete or partial response to first-line platinum-based chemotherapy, and as maintenance therapy in patients with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer harboring deleterious or suspected deleterious germline BRCA mutations and in complete or partial response to platinum-based chemotherapy (FDA.gov).

DrugClasses PARP Inhibitor (Pan) 30
CAS Registry Number 1038915-60-4
NCIT ID C80059

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Niraparib Abemaciclib Niraparib 0 1
Abiraterone + Apalutamide + Niraparib + Prednisone Abiraterone Apalutamide Niraparib Prednisone 0 1
Abiraterone + Leuprolide + Niraparib + Prednisone Abiraterone Leuprolide Niraparib Prednisone 0 1
Abiraterone + Niraparib Abiraterone Niraparib 0 1
Abiraterone + Niraparib + Prednisone Abiraterone Niraparib Prednisone 4 4
Anlotinib + Niraparib Anlotinib Niraparib 0 0
Apalutamide + Niraparib Apalutamide Niraparib 0 1
AsiDNA + Niraparib AsiDNA Niraparib 0 1
Atezolizumab + Cobimetinib + Niraparib Atezolizumab Cobimetinib Niraparib 0 1
Atezolizumab + Niraparib Atezolizumab Niraparib 0 2
AZD6482 + Niraparib AZD6482 Niraparib 1 0
Bevacizumab + Dostarlimab-gxly + Niraparib Bevacizumab Dostarlimab-gxly Niraparib 0 2
Bevacizumab + Niraparib Bevacizumab Niraparib 0 6
Cabozantinib + Niraparib Cabozantinib Niraparib 0 1
Carboplatin + Gemcitabine + Niraparib + Paclitaxel + Pegylated liposomal doxorubicin Carboplatin Gemcitabine Niraparib Paclitaxel Pegylated liposomal doxorubicin 0 0
Carboplatin + Niraparib Carboplatin Niraparib 0 1
Carboplatin + Niraparib + Paclitaxel Carboplatin Niraparib Paclitaxel 0 4
Ceralasertib + Niraparib Ceralasertib Niraparib 1 0
Cetrelimab + Niraparib Cetrelimab Niraparib 0 2
CHIR99021 + Niraparib CHIR99021 Niraparib 0 0
Cisplatin + Dostarlimab-gxly + Niraparib Cisplatin Dostarlimab-gxly Niraparib 0 1
Cobimetinib + Niraparib Cobimetinib Niraparib 0 1
Copanlisib + Niraparib Copanlisib Niraparib 0 1
Cyclophosphamide + Doxorubicin + Niraparib Cyclophosphamide Doxorubicin Niraparib 0 1
Cyclophosphamide + Doxorubicin + Niraparib + Pegfilgrastim Cyclophosphamide Doxorubicin Niraparib Pegfilgrastim 0 1
CYT01B + Niraparib CYT01B Niraparib 0 0
DAN-222 + Niraparib DAN-222 Niraparib 0 1
Dostarlimab-gxly + Niraparib Dostarlimab-gxly Niraparib 0 26
Elacestrant + Niraparib Elacestrant Niraparib 0 1
Elimusertib + Niraparib Elimusertib Niraparib 0 1
Everolimus + Niraparib Everolimus Niraparib 0 1
Fulvestrant + Niraparib Fulvestrant Niraparib 0 1
GSK4524101 + Niraparib GSK4524101 Niraparib 0 1
Ipilimumab + Niraparib Ipilimumab Niraparib 0 1
Irinotecan + Niraparib Irinotecan Niraparib 0 1
LY2090314 + Niraparib LY2090314 Niraparib 0 0
M4076 + Niraparib M4076 Niraparib 0 0
Neratinib + Niraparib Neratinib Niraparib 0 1
Niraparib Niraparib 7 56
Niraparib + Nivolumab Niraparib Nivolumab 0 1
Niraparib + Oregovomab Niraparib Oregovomab 0 1
Niraparib + Osimertinib Niraparib Osimertinib 0 1
Niraparib + OT-82 Niraparib OT-82 0 0
Niraparib + Paclitaxel Niraparib Paclitaxel 0 1
Niraparib + Panitumumab Niraparib Panitumumab 0 1
Niraparib + Pembrolizumab Niraparib Pembrolizumab 0 3
Niraparib + Radiotherapy Niraparib Radiotherapy 0 0
Niraparib + Radium Ra 223 dichloride Niraparib Radium Ra 223 dichloride 0 1
Niraparib + RP-3500 Niraparib RP-3500 1 1
Niraparib + Simurosertib Niraparib Simurosertib 0 0
Niraparib + SN-38 Niraparib SN-38 0 0
Niraparib + SY-1365 Niraparib SY-1365 0 0
Niraparib + Telaglenastat Niraparib Telaglenastat 0 1
Niraparib + Temozolomide Niraparib Temozolomide 0 3
Niraparib + Tislelizumab Niraparib Tislelizumab 0 0
Niraparib + Trastuzumab Niraparib Trastuzumab 0 1
Niraparib + Trastuzumab Duocarmazine Niraparib Trastuzumab Duocarmazine 0 1
Niraparib + VX-803 Niraparib VX-803 0 2
Niraparib + ZEN-3694 Niraparib ZEN-3694 0 1
Niraparib + ZN-c3 Niraparib ZN-c3 0 1


Additional content available in CKB BOOST