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Drug Name Elacestrant
Trade Name Orserdu
Synonyms RAD1901
Drug Descriptions

Orserdu (elacestrant) is a selective estrogen receptor degrader that down-regulates ER and ER-regulated genes, resulting in anti-tumor activity and may be effective in cells resistant to CDK4/6 inhibitors (PMID: 28473534, PMID: 31852484). Orserdu (elacestrant) is FDA approved for use in postmenopausal women or adult men with ER-positive, ERBB2 (HER2)-negative, ESR1 (ER alpha)-mutated advanced or metastatic breast cancer progressed on endocrine therapy (FDA.gov).

DrugClasses Hormone - Anti-estrogens 25
CAS Registry Number 722533-56-4
NCIT ID C120211

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Elacestrant Abemaciclib Elacestrant 0 4
Alpelisib + Elacestrant Alpelisib Elacestrant 0 1
Elacestrant Elacestrant 0 7
Elacestrant + Everolimus Elacestrant Everolimus 0 1
Elacestrant + Fulvestrant Elacestrant Fulvestrant 0 0
Elacestrant + MEN1611 Elacestrant MEN1611 0 0
Elacestrant + Niraparib Elacestrant Niraparib 0 1
Elacestrant + Onapristone Elacestrant Onapristone 0 1
Elacestrant + Palbociclib Elacestrant Palbociclib 0 2
Elacestrant + Ribociclib Elacestrant Ribociclib 0 2
Elacestrant + Samuraciclib Elacestrant Samuraciclib 0 1
Elacestrant + Triptorelin Elacestrant Triptorelin 0 1


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