Drug Detail


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Drug Name ZN-c3
Trade Name
Synonyms ZNc3|ZN c3|azenosertib
Drug Descriptions

ZN-c3 is a small molecular inhibitor of WEE1 and inhibition of WEE1 increases DNA damage in cancer cells to induce programmed cell death (J Clin Oncol 41, 2023 (suppl 16; abstr 5513)).

DrugClasses WEE1 Inhibitor 6
CAS Registry Number NA
NCIT ID C167064


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bevacizumab + Pembrolizumab + ZN-c3 Bevacizumab Pembrolizumab ZN-c3 0 1
Bevacizumab + ZN-c3 Bevacizumab ZN-c3 0 1
Carboplatin + Pembrolizumab + ZN-c3 Carboplatin Pembrolizumab ZN-c3 0 1
Carboplatin + ZN-c3 Carboplatin ZN-c3 0 1
Cetuximab + Encorafenib + ZN-c3 Cetuximab Encorafenib ZN-c3 0 1
Gemcitabine + ZN-c3 Gemcitabine ZN-c3 0 1
Niraparib + ZN-c3 Niraparib ZN-c3 0 1
Paclitaxel + ZN-c3 Paclitaxel ZN-c3 0 0
Pegylated liposomal doxorubicin + ZN-c3 Pegylated liposomal doxorubicin ZN-c3 0 1
Pembrolizumab + ZN-c3 Pembrolizumab ZN-c3 0 1
Talazoparib + ZN-c3 Talazoparib ZN-c3 0 1
ZN-c3 ZN-c3 0 6
ZN-c3 + ZN-d5 ZN-c3 ZN-d5 0 1

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