Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name ZN-c3
Trade Name
Synonyms ZNc3|ZN c3|azenosertib
Drug Descriptions

ZN-c3 is a small molecular inhibitor of WEE1 and inhibition of WEE1 increases DNA damage in cancer cells to induce programmed cell death (J Clin Oncol 41, 2023 (suppl 16; abstr 5513)).

DrugClasses WEE1 Inhibitor 6
CAS Registry Number NA
NCIT ID C167064

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Bevacizumab + Pembrolizumab + ZN-c3 Bevacizumab Pembrolizumab ZN-c3 0 1
Bevacizumab + ZN-c3 Bevacizumab ZN-c3 0 1
Carboplatin + Pembrolizumab + ZN-c3 Carboplatin Pembrolizumab ZN-c3 0 1
Carboplatin + ZN-c3 Carboplatin ZN-c3 0 1
Cetuximab + Encorafenib + ZN-c3 Cetuximab Encorafenib ZN-c3 0 1
Gemcitabine + ZN-c3 Gemcitabine ZN-c3 0 1
Niraparib + ZN-c3 Niraparib ZN-c3 0 1
Paclitaxel + ZN-c3 Paclitaxel ZN-c3 0 0
Pegylated liposomal doxorubicin + ZN-c3 Pegylated liposomal doxorubicin ZN-c3 0 1
Pembrolizumab + ZN-c3 Pembrolizumab ZN-c3 0 1
Talazoparib + ZN-c3 Talazoparib ZN-c3 0 1
ZN-c3 ZN-c3 0 5
ZN-c3 + ZN-d5 ZN-c3 ZN-d5 0 1


Additional content available in CKB BOOST