Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name ZN-c3
Trade Name
Synonyms ZNc3|ZN c3
Drug Descriptions

ZN-c3 is a small molecular inhibitor of WEE1 and inhibition of WEE1 increases DNA damage in cancer cells to induce programmed cell death (NCI Drug Dictionary).

DrugClasses WEE1 Inhibitor 5
CAS Registry Number NA
NCIT ID C167064


  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"


  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Bevacizumab + Pembrolizumab + ZN-c3 Bevacizumab Pembrolizumab ZN-c3 0 1
Bevacizumab + ZN-c3 Bevacizumab ZN-c3 0 1
Carboplatin + ZN-c3 Carboplatin ZN-c3 0 1
Gemcitabine + ZN-c3 Gemcitabine ZN-c3 0 1
Niraparib + ZN-c3 Niraparib ZN-c3 0 1
Pegylated liposomal-doxorubicin + ZN-c3 Pegylated liposomal-doxorubicin ZN-c3 0 1
Pembrolizumab + ZN-c3 Pembrolizumab ZN-c3 0 1
Talazoparib + ZN-c3 Talazoparib ZN-c3 0 1
ZN-c3 ZN-c3 0 4

Additional content available in CKB BOOST