Therapy Detail

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Therapy Name ZN-c3
Synonyms
Therapy Description

ZN-c3 is a small molecular inhibitor of WEE1 and inhibition of WEE1 increases DNA damage in cancer cells to induce programmed cell death (J Clin Oncol 41, 2023 (suppl 16; abstr 5513)).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ZN-c3 ZNc3|ZN c3|azenosertib WEE1 Inhibitor 6 ZN-c3 is a small molecular inhibitor of WEE1 and inhibition of WEE1 increases DNA damage in cancer cells to induce programmed cell death (J Clin Oncol 41, 2023 (suppl 16; abstr 5513)).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04814108 Phase II ZN-c3 A Study of ZN-c3 in Women With Recurrent or Persistent Uterine Serous Carcinoma Recruiting USA | CAN | AUS 1
NCT05128825 Phase II ZN-c3 A Study of ZN-c3 in Subjects With Malignant Tumors Recruiting USA | FRA | AUS 0
NCT05368506 Phase I ZN-c3 ZN-c3 for the Treatment of Metastatic Triple-Negative Breast Cancer and Advanced Ovarian Cancer Withdrawn 0
NCT05682170 Phase Ib/II ZN-c3 + ZN-d5 ZN-c3 Study of the ZN-d5 and ZN-c3 in Subjects With Acute Myeloid Leukemia (AML) Recruiting USA 0
NCT04158336 Phase Ib/II ZN-c3 Talazoparib + ZN-c3 Pembrolizumab + ZN-c3 A Study of ZN-c3 in Participants With Solid Tumors Recruiting USA 0


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