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ZN-c3 is a small molecular inhibitor of WEE1 and inhibition of WEE1 increases DNA damage in cancer cells to induce programmed cell death (NCI Drug Dictionary).
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|ZN-c3||ZNc3|ZN c3||WEE1 Inhibitor 5||ZN-c3 is a small molecular inhibitor of WEE1 and inhibition of WEE1 increases DNA damage in cancer cells to induce programmed cell death (NCI Drug Dictionary).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT05368506||Phase I||ZN-c3||ZN-c3 for the Treatment of Metastatic Triple-Negative Breast Cancer and Advanced Ovarian Cancer||Withdrawn||0|
|NCT04158336||Phase Ib/II||ZN-c3 Talazoparib + ZN-c3 Pembrolizumab + ZN-c3||A Study of ZN-c3 in Participants With Solid Tumors||Recruiting||USA||0|
|NCT04814108||Phase II||ZN-c3||A Study of ZN-c3 in Women With Recurrent or Persistent Uterine Serous Carcinoma||Recruiting||USA | CAN||2|
|NCT05682170||Phase Ib/II||ZN-c3 + ZN-d5 ZN-c3||Study of the ZN-d5 and ZN-c3 in Subjects With Acute Myeloid Leukemia (AML)||Recruiting||USA||0|
|NCT05128825||Phase II||ZN-c3||A Study of ZN-c3 in Subjects With Malignant Tumors||Recruiting||USA||0|