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Drug Name Encorafenib
Trade Name Braftovi
Synonyms LGX818
Drug Descriptions

Braftovi (encorafenib) is an inhibitor of Raf kinase with selective activity against BRAF V600E, resulting in growth inhibition (PMID: 24864047). Braftovi (encorafenib) is FDA approved for use in combination with Mektovi (binimetinib) in patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation, and in combination with Erbitux (cetuximab) in patients with metastatic colorectal cancer with BRAF V600E(FDA.gov).

DrugClasses BRAF Inhibitor 20
CAS Registry Number 1269440-17-6
NCIT ID C98283

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Alpelisib + AZD6482 + Binimetinib + Encorafenib AZD6482 Alpelisib Binimetinib Encorafenib 1 0
Alpelisib + AZD6482 + Encorafenib AZD6482 Alpelisib Encorafenib 1 0
Alpelisib + Cetuximab + Encorafenib Alpelisib Cetuximab Encorafenib 5 1
Alpelisib + Encorafenib Alpelisib Encorafenib 1 0
Alpelisib + Encorafenib + GSK2636771 Alpelisib Encorafenib GSK2636771 1 0
AZD6482 + Binimetinib + Encorafenib AZD6482 Binimetinib Encorafenib 0 0
AZD6482 + Binimetinib + Encorafenib + NVP-AEW541 AZD6482 Binimetinib Encorafenib NVP-AEW541 1 0
AZD6482 + Encorafenib AZD6482 Encorafenib 2 0
AZD6482 + Encorafenib + NVP-AEW541 AZD6482 Encorafenib NVP-AEW541 1 0
Binimetinib + Buparlisib + Encorafenib Binimetinib Buparlisib Encorafenib 0 1
Binimetinib + Capmatinib + Encorafenib Binimetinib Capmatinib Encorafenib 0 1
Binimetinib + Cetuximab + Encorafenib Binimetinib Cetuximab Encorafenib 1 3
Binimetinib + Encorafenib Binimetinib Encorafenib 17 21
Binimetinib + Encorafenib + Infigratinib Binimetinib Encorafenib Infigratinib 0 1
Binimetinib + Encorafenib + Ipilimumab + Nivolumab Binimetinib Encorafenib Ipilimumab Nivolumab 0 1
Binimetinib + Encorafenib + Nivolumab Binimetinib Encorafenib Nivolumab 0 4
Binimetinib + Encorafenib + Panitumumab Binimetinib Encorafenib Panitumumab 0 0
Binimetinib + Encorafenib + Pembrolizumab Binimetinib Encorafenib Pembrolizumab 1 2
Binimetinib + Encorafenib + PF-06801591 Binimetinib Encorafenib PF-06801591 0 1
Binimetinib + Encorafenib + Ribociclib Binimetinib Encorafenib Ribociclib 0 2
Buparlisib + Encorafenib Buparlisib Encorafenib 1 1
Capmatinib + Encorafenib Capmatinib Encorafenib 0 1
Cetuximab + Encorafenib Cetuximab Encorafenib 7 3
Cetuximab + Encorafenib + ERAS-007 Cetuximab ERAS-007 Encorafenib 0 1
Cetuximab + Encorafenib + Fluorouracil + Irinotecan + Leucovorin Cetuximab Encorafenib Fluorouracil Irinotecan Leucovorin 0 1
Cetuximab + Encorafenib + Fluorouracil + Leucovorin + Oxaliplatin Cetuximab Encorafenib Fluorouracil Leucovorin Oxaliplatin 0 1
Cetuximab + Encorafenib + LGK974 Cetuximab Encorafenib LGK974 0 1
Cetuximab + Encorafenib + Nivolumab Cetuximab Encorafenib Nivolumab 0 1
Cetuximab + Encorafenib + PF-07284892 Cetuximab Encorafenib PF-07284892 0 1
CGM097 + Encorafenib CGM097 Encorafenib 1 0
Dabrafenib + Encorafenib Dabrafenib Encorafenib 0 0
Encorafenib Encorafenib 9 5
Encorafenib + GSK2636771 Encorafenib GSK2636771 2 0
Encorafenib + GSK2636771 + unspecified IGF-1R antibody Encorafenib GSK2636771 unspecified IGF-1R antibody 1 0
Encorafenib + Infigratinib Encorafenib Infigratinib 0 1
Encorafenib + Ipilimumab + Nivolumab Encorafenib Ipilimumab Nivolumab 0 1
Encorafenib + Panitumumab Encorafenib Panitumumab 2 0
Encorafenib + Pictilisib Encorafenib Pictilisib 1 0
Encorafenib + Ribociclib Encorafenib Ribociclib 1 2
Encorafenib + Trametinib Encorafenib Trametinib 4 0
Encorafenib + unspecified IGF-1R antibody Encorafenib unspecified IGF-1R antibody 1 0


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