Drug Detail


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Drug Name LGK974
Trade Name
Synonyms WNT974|WNT-974
Drug Descriptions

LGK974 (WNT-974) binds to and inhibits porcupine (PORCN), resulting in decreased secretion of Wnt ligands and concomitant decrease in Wnt signaling, potentially resulting in reduced cell growth in tumors with dysregulated Wnt signaling (PMID: 32104684).

DrugClasses WNT Inhibitor 15
CAS Registry Number 1243244-14-5
NCIT ID C116860


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cetuximab + Encorafenib + LGK974 Cetuximab Encorafenib LGK974 0 1
LGK974 LGK974 0 2
LGK974 + Spartalizumab LGK974 Spartalizumab 0 1

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