Therapy Detail

Therapy Name LGK974 + Spartalizumab
Synonym
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
LGK974 WNT974 WNT Inhibitor 9 LGK974 binds to and inhibits porcupine (PORCN), resulting in decreased secretion of Wnt ligands and concomitant decrease in Wnt signaling, potentially resulting in reduced cell growth in tumors with dysregulated Wnt signaling (NCI Drug Dictionary).
Spartalizumab PDR001 Immune Checkpoint Inhibitor 99 PD-L1/PD-1 antibody 51 Spartalizumab (PDR001) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (NCI Drug Dictionary).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Clinical Trial Phase Therapies Title Recruitment Status
NCT01351103 Phase I LGK974 LGK974 + Spartalizumab A Study of LGK974 in Patients With Malignancies Dependent on Wnt Ligands Recruiting