Drug Detail


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Drug Name DCC-3116
Trade Name
Synonyms DCC 3116|DCC3116
Drug Descriptions

DCC3116 selectively inhibits ULK1/2, leading to decreased phosphorylation of its substrate ATG13 and inhibition of autophagosome formation, and may lead to inhibition of tumor cell growth (Mol Cancer Ther 2019;18(12 Suppl):Abstract nr B129).

CAS Registry Number NA
NCIT ID C180331


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Afatinib + DCC-3116 Afatinib DCC-3116 0 0
Binimetinib + DCC-3116 Binimetinib DCC-3116 0 1
Cetuximab + DCC-3116 + Encorafenib Cetuximab DCC-3116 Encorafenib 0 1
DCC-3116 DCC-3116 0 1
DCC-3116 + Osimertinib DCC-3116 Osimertinib 0 0
DCC-3116 + Ripretinib DCC-3116 Ripretinib 0 1
DCC-3116 + Sotorasib DCC-3116 Sotorasib 0 1
DCC-3116 + Trametinib DCC-3116 Trametinib 0 1

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